7/10/21 Flashcards
Treatment Options of Androgenic Alopecia? (6 points)
- No Treatment
- Hair Piece
- Topical Minoxidil 2-5%
- Oral Finasteride 1mg Daily
- Oral Dutasteride 0.5mg daily
- Surgery
How does Finasteride work and Side effects of Finasteride (give me 4)
- Mode of Action: inhibits 5-alpha-reductase (5AR)
- Infrequent → impotence, decreased libido, ejaculation disorder
- Rare → breast tenderness + enlargement, allergic reaction, poor semen quality, infertility and depression
Treatment of Hyperhidrosis (4 steps)
- Antiperspirant
- Iontophresis
- Iontophresis + Anticholinergic, Anticholinergic, Botox
- Surgical Sympatectomy
What cause of neck pain are patients with Down’s Syndrome more prone to? How do you diagnose this? What are the associated symptoms? (Give me 3)
Atalanto-Axial Instability
- excessive mobility of the articulation of the atlas (C1) and the axis (C2) → may lead to subluxation of the cervical spine.
- diagnosis: lateral neck radiographs
- symptoms: neck pain, torticollis, gait abnormalities, loss of bowel or bladder control or quadriplegia or quadriplegia
What are red flags of neck pain? (12 points - name as many, at least 9)
- Significant Trauma
- Infective symptoms including Fever >38
- Constant Pain (day and night)
- Down’s Syndrome
- History of Cancer
- Constitutional Symptoms - night sweats, weight loss
- History of RA or Ankylosing Spondylitis
- Age >50yo
- Pain at Multiple Sites
- Neurology - radicular pain down arm, spinal cord pathology
- Anterior Neck (Throat) Pain
- Ripping/Tearing Neck Sensation
How do you treat hyperprolactinaemia? Be Specific.
- Cabergoline 0.5mg weekly in 1 or 2 doses → increasing by 0.5mg in monthly intervals up to maximum 3mg
- Treatment of medical indicated lactation suppression (post-still birth/severe mastitis)/galactorrhoea
8 categories of causes of hyperprolactinaemia.
- Prolactinoma
- Medications -> quite a few.
- Neurogenic Causes -> stress, chest wall trauma, breast stimulation
- Pseudohypnatraemia
- Pregnancy
- Pituitary Stalk Pathology -> trauma, surgery and tumour
- Systemic Illness > thyroid, kidney, liver, epilepsy
- Hypothalamic Disorder -> tumour, infiltration, surgery
Medication that can cause hyperprolactinaemia. (9 drugs - give me 4)
- antipsychotics, methyldopa, metoclopramide, domperidone, opioids, SSRIs, TCAs, cannabis, OCP
Other than dopamine agonist therapy, name 3 other therapies for hyperprolactinaemia?
- Combined Oral Contraceptive Therapy → used for women with a microprolactinoma who do not desire fertility and do not have distressing symptoms
- Pituitary Surgery → patients who cannot tolerate or are resistant to dopamine agonists
- Radiotherapy → reserved for prolactinomas that continue to expand despite surgical and drug therapy
What neurological conditions are cluster headaches a subgroup of? What are cluster headaches associated with?
- subtype of trigeminal autonomic cephalgia → associated with structural lesions of the pituitary
What are cluster headaches aka? What is the nature and frequency and duration of cluster headaches?
- aka “suicide headaches” → stabbing, boring headaches
- 0.5 to 8 episodes daily, each lasting 15mins-3 hours
What are the main charateristics of a cluster headache? Males or Female predominance? Triggers?
- male > female
- Unilateral and side-locked (always affects same side of head), usually follows distribution of first division of the trigeminal nerve
- Unilateral autonomic features → tearing, conjunctival irritation/injection, ptosis, nasal stuffiness/rhinorrhoea, fullness of the ear, tinnitus, facial flushing or sweating). Possible photophobia and phonophobia
- Patient is usually agitated and restless
- Triggered by alcohol
Treatment of an acute cluster headache? 2 points + 1 bonus
- Sumatriptan 6mg subcut
- Get relief from high flow O2 → if effective oxygen can be used at home
- A greater occipital nerve block can be used a bridging treatment
Prophylaxis of cluster headaches + point of consideration given this treatment choice.
- Verapamil IR 80mg TDS for 2/52 then 120mg TDS for 2/52 then 160mg TDS. Repeat ECG
- Fewest side effects
- Heart block may only arise 10/7 after starting or increasing dose
What is Diabetic Amyotrophy? How does it progress?
- Acute, asymmetric focal onset of pain followed by weakness involving the proximal leg, with associated autonomic failure and weight loss.
- Progression occurs over months and is followed by partial recovery in most patients