14/10/21 Flashcards
Clinical Diagnosis of COPD (3 points)
- Symptoms of exertional breathlessness, cough and sputum
- History of smoking, or exposure to other noxious agents
- Post-Bronchodilator FEV1/FVC <0.7
What constitutes a positive bronchodilator response?
Adults: 12% or 200ml change
Children: 12% change
Causes of Obstructive Lung Disease (6 points)
- COPD
- Asthma
- Bronchiectasis
- Cystic Fibrosis
- Bronchiolitis
- Alpha1-Antitrypsin Deficiency
Causes of Restrictive Lung Disease (8 points)
- Pulmonary Fibrosis
- Neuromuscular Disorders
- Congestive Cardiac Failure
- Sarcoidosis
- Obesity
- Interstitial Lung Disease (ILD)
- Pneumonia
- Pleural Disease → pleural effusion or diffuse pleural thickening
What stage of COPD do you use ICS?
Moderate
Examples of LAMA and LABA. 1 each
LAMA - tioptropium
LABA - salmeterol
Ranges for overt and subclinical hypothyroidism in pregnancy?
Overt -> TSH >2.5 with increased T4 or TSH >10 irrespective of T4
Subclinical -> TSH 2.5-10 with normal T4
Investigations in hypothyroidism in pregnancy. Why are these two tests important?
TSH and T4 -> all the risk associated with hypothyroidism (prematurity, low birth weight and miscarriage)
TPO Antibodies -> thyroid peroxidase antibody → may increase the risk of pregnancy complications INCLUDING IN WOMEN WITH A TSH IN THE NORMAL RANGE.
Management steps for overt hypothyroidism diagnosed in pregnancy?
- commence thyroixine 50-100microg/day
- refer to endocrinologist
- consider TPO Antibody testing
- repeat TFTs in 4 weeks
What is a keratoacanthoma? What are the clinical features?
Benign squamoproliferative lesion → can appear suddenly and grow rapidly
- same sites as SCC
- presents over weeks to a few months → enlarging nodule with a central keratotic core
Differential Diagnoses for Keratoacanthoma
- Squamous Cell Carcinoma
- Nodular Basal Cell Carcinoma
- Merkel Cell Carcinoma
- Prurigo Nodule
- Giant Molluscum Contagiosum
- Deep Fungal Infection
- Nodular Kaposi’s Sarcoma
- Cutaneous Metastases
Treatment for Keratoacanthoma. What is the significance of this?
- Surgical Excision → 3-5mm margin
- difficult to distinguish between a keratoacanthoma and an SCC on clinical diagnosis or partial biopsies
Differential Diagnosis for 2nd and 3rd Trimester PV bleeding in pregnancy (9 points)
- Bloody Show associated with labour
- Placenta Previa
- Placental Abruption
- Uterine Rupture (rare)
- Vasa Previa (rare)
- Cervical Pathology - cervicitis
- Vaginal Pathology
- Uterine Pathology - polyps, infection/inflammation, trophoblastic disease
- Non-Tubal Ectopic Pregnancy
Investigations in 2nd or 3rd trimester PV bleeding (5 points)
- FBE
- RhesusD negative → need anti-D immune globulin → protects against RhD alloimmunisation
- Obstetric U/S
- Group and Hold
- Coagulation Studies
- Fetal Fibronectin (fFN)
Discuss the fetal fibronectin test. What is it and what are the associated benefits?
- glycoprotein found at boundary between the amniotic sac and the uterus
- performed in women with suspected premature labour
- Cervical or Vaginal fluid sample → sample collected to be analysed for fFN
- Positive fFN → can be related to causes other than risk of pre-term delivery
- Negative fFN → highly predictive that preterm delivery will not occur within in the next 7-14 days
- therefore can reduce unnecessary hospitalisations and drug therapies