30/10/21 Flashcards
Risk Factors for Erectile Dysfunction (8 points)
- Increased Age
- CV disease + Risk Factors for CV Disease → Obesity, Diabetes, Sedentary Lifestyle, Obesity, Diabetes, HTN, Dyslipidaemia, OSA, Smoking
- Endocrine Disorders → T2DM, Androgen Deficiency, Thyroid Disorders, Hyperprolactinaemia
- Neurological Conditions affecting brain, spinal cord or autonomic nervous system
- Medication → beta-blockers, thiazides, antidepressants, anti-psychotics, anti-androgens
- Prostate Cancer Therapy
- Penile Disorders
- Recreational Drug or Alcohol Use - Cocaine…
First Line and Second Line Therapy for Erectile Dysfunction.
- PDE5 Inhibitors
2. Vacuum Erection Devices or Intracavernosal Injection
What constitutes low and high risk of death or significant morbidity with sexual exertion. (3, 5)
- *Low Risk**
- NO uncontrolled hypertension
- NO recent myocardial infarction (within last 8 weeks)
- Can climb 2 flights of stairs in 10 seconds
- *High Risk** - needs cardiology review prior to engaging in sexual intercourse
- ACS in the last 2 weeks (without revascularisation)
- High-Risk Arrhythmias
- Severe Aortic Stenosis
- Symptomatic Hypertrophic Obstructive Cardiomyopathy
- New York Heart Association - Class IV Symptoms
History for Uveitis (3 points + 1 bonus)
- painful red eye → deep ache that radiates the periorbital or temple area
- worse with movement and accomodation
- begins with general sensitivity around the eye and progressing to photophobia, redness and visual loss
- +/- blurred vision
- develops over several days
6 examination for uveitis (3 key + 3 bonus) plus findings for 3 key examinations
Visual Acuity - can be reduced in posterior uvetitis
Pupils - constricted, may be irregular and is sluggish in response to light. Direct and consensual photophobia
Slit Lamp Examination:
- Conjunctiva → diffusely injected conjunctiva with circumcorneal involvement aka “ciliary flush” → no perlimbal sparing as occurs in conjunctivitis. Tearing but no purulent discharge
- Examine cornea, anterior chamber and posterior chamber as well
Bonus:
Red Reflex - may be normal or altered (secondary cataract)
Tonometry - check for secondary glaucoma
Fundoscopy - look for evidence of choroiditis or retinitis, or complications such as retinal detachment
Management of Uveitis (5 points)
- Urgent Referral to Ophthalmology
- Seek and Treat Underlying Causes + Treat complications such as glaucoma
- Mydriatics → sympathomimetics such as phenylephrine HCl → this will present formatino of synechiae by pupillary dilation
- Parasympatholytic Agents → atropine, cyclopentolate → produce mydriasis and cycloplegia which reduces pain and photophobia
- Topical Corticosteroids following consultation with ophthalmology and consideration of possible infectious aetiology
Definition of Cushings Syndrome
Definition: Syndrome to describe the chemical features of increased free circulating glucocorticoid.
Clinical Features/History of Cushing Syndrome (9 points)
- Change in Appearance → as disorder progresses body to quoted configuration of a lemon on matchsticks
- Central Weight Gain → Truncal Obesity
- Hair Growth and Acne in Females
- Muscle Weakness
- Amenorrhoea/Oligomenorrhoea
- Thin Skin + Spontaneous Bruising
- Polymyalgia/Polydipsia
- Insomnia
- Depression
Examination Findings of Cushings Syndrome (4 points)
- Moon Face
- Buffalo Hump
- Purple Striae
- Large Trunk and Thin Limbs → “lemon with matchsticks” sign
Investigations of Cushings Syndrome (2 points)
- Plasma Cortisol
- Overnight Dexamethasone Suppression Tests
How to determine nicotine dependence? (3 points)
- Minutes after waking for first cigarette → if smoking <30mins from waking
- Number of cigarettes/day → if smoking >10 cigarettes/day
- Cravings or Withdrawal Symptoms in previous quit attempts
Contraindication in regards to age range for NRT?
Age <12 years old. Suitable for adolescence.
Main options for smoking cessation pharmacotherapy. (2 points)
- NRT
2. Varenicline
Classification of Acne (3 stages)
Mild → few comedones and papulopustules, no scarring - lesions are confined to the forehead, nose and chin (T-zone)
Moderate → numerous papulopustules and comedones, with some nodules but no scarring - lesions affect extensive areas of the face and sometimes the trunk
Severe → nodules, cysts and scarring - lesions may be confined to the face but commonly also affect the trunk
Initial Therapy for Mild Acne. Be Specific.
Benzoyl Peroxide 5% (unless history of atopic dermatitis or dry or sensitive skin)
- if mild acne on the chest or back - use a wash
- if history of atopic dermatitis or dry or sensitive skin → start with benzyl peroxide 2.5%
If initial therapy was not enough, and mainly comedonal acne - what is the next step?
Change to Topical Retinoid
1. Adapalene 0.1% cream or gel topically, for 6 weeks then review
If initial therapy was not enough, and comedonal AND inflammatory acne - what is the next step?
If comedonal AND inflammatory → change to topical combination of benzoyl perioxide and retinoid (if more comedonal) or benzoyl peroxide and antiobiotic (if more inflammatory)
Benzoyl Peroxide + Adapalene 2.5% + 0.1% gel topically, once daily for 6 weeks then review
- for acne that is mostly comedonal
Benzoyl Peroxide + Clindamycin 5% + 1% gel topically, once daily for 6 weeks then review
- for acne that is comedonal AND inflammatory
If no improvement in 6/52 then what next? Males vs Females?
Males: Oral Abx
Females: COCP/Spironolactone/Oral ABx
ABx: Doxycycline 50-100mg orally, once daily for 6 weeks, then review
COCP: Ethinylestradiol + Cyproterone 35micrograms + 2mg orally, OD on days 1-21 of 28 days cycle
Spironolactone 25-50mg orally, once daily, increasing gradually to 50-100mg once daily as tolerated, review in 6 months
If no improvement following Oral ABx/COCP/Spironolactone - next step? Discuss some side effects of this.
Refer to specialist for oral isotretinoin.
Adverse Effects → dry lips and dryness elsewhere (eyes and mucosal lining of the nose), early flare of acne, sun sensitivity, less common is impaired night vision
Who should get cyclical combined MHT?
With Endometrial Tissue who:
- PERImenopausal → <12 months since last period as breakthrough bleeding can occur on continuous MHT
- premature ovarian insufficiency