5/12/21 Flashcards

1
Q

Discuss commencement of insulin. Dosing and titration numbers.

A
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2
Q

Counselling when starting insulin?

A

NDSS medication change registration → to allow patients access to strips and pen needles

timing and frequency of SMBG, timing of meals, dose adjustment

impact of diet → carb counting, impact of irregular eating patterns - religious fasting, intermittent fasting etc.

impact of physical activity

hypoglycaemia management

insulin delivery techniques → rotation of sites, injection technique, storage of insulin

weight management and mitigation of weight gain

Sick day management

Notification re: driving

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3
Q

Prevent progression or worsening of diabetic retinopathy?

A

To reduce risk and slow progression of Diabetic Retinopathy → optimise glycaemic control, blood lipid levels and bloods pressure + smoking cessation

monitor progression of diabetic retinopathy with ophthalmologist

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4
Q

Risk factors of progression of Diabetic Retinopathy?

A

Poor Glycaemic Control

Poor Lipds

Poorly controlled HTN

Anaemia

Pregnancy

Microalbuminuria

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5
Q

Examination for Peripheral Neuropathy

A
  1. 10g monofilament - pressure sesnation
  2. Ankle Reflexes
  3. Vibration Sensation on dorsum of great toe
  4. Protective sensation - 10g monofilament
  5. Pinprick sensation
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6
Q

Investigations in Peripheral Neuropathy?

A

Diabetes

B12 Deficiency

Hypothyroidism

Renal Disease

Excessive Alcohol Consumption

Bloods: B12, TFT, UEC, HbA1c

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7
Q

Medical Management of Peripheral Neuropathy?

A

Review Glycemic Control

Symptomatic Management

Anticonvulsants → pregabalin (75mg po daily, review in 7 days), gabapentin, valproate

Antidepressants → amitryptiline (10mg nocte review in 7/7), duloxetine, venlafaxine

Topical Nitrate Spray

Opioid Analgesics

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8
Q

Examples of SGLT2 inhibitors and dosing please.

A

Dapagliflozin 10mg PO Daily

Empagliflozin 10mg PO Daily

Ertugliflozin 5mg PO Daily

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9
Q

OPtions and dosing of Dpp4 inhibitors?

A

Aloglitptin 25mg once daily

Linagliptin 5mg once daily (safe in all stages of renal impairment)

Saxagliptin 5mg once daily

Sitagliptin 100mg once daily

Vildagliptin 50mg BD

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10
Q

Which med in patients with t2dm, poor glycaemic control on metformin + CVD?

A

SGLT2 inhibitors - flozins

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11
Q

Counselling for SGLT2 Inhibitors

A

increased risk of UTI, urinary frequency or incontinence

increased risk of euglycaemic ketoacidosis

cease medication at least 3 days prior to surgery or procedures that require hospital stay. if day procedures, cease day of the procedure.

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12
Q

CV screening in PCOS? What about in the context of pregnancy?

A

Smoking

BP - annual check

Lipid profile - annually if BMI >25

Screen with OGTT, fasting glucose or HbA1c

if high-risk use OGTT (e.g history of GDM, Impaired Fasting Glucose, Impaired Glucose Tolerance, FHx of diabetes, hypertension or high risk ethnicity) → every 1-3 years (annually if IFG/IGT)

If PCOS and planning pregnancy → complete OGTT (esp if over 30yo)

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13
Q

Pre-Conception Consult

A

CST

No safe alcohol

Smoking Cessation

Safe Exercise - moderate intensity 150mins/week

Folic Acid supplementation - 5mg 1 months prior to planned conception

Social Supports + Domestic Partner Violence

Mental Health

Preconception Genetic Screening

Diet - healthy well balanced diet

if overweight/obese - drop 5-10% weight prior to conception

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14
Q

Folic Acid Supplementation in pregs? Same for all?

A

400-500 microgs for at least 4 weeks prior to pregnancy and for the first 12 weeks of gestation

if high risk → 5mg daily same time frame

  • high risk -> malabsorption, BMI >30, GDM, anticonvulsant medication, previous neural tube defect
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15
Q

Examinations in First Antenatal Consult

A

BP

BMI

HR

Thyroid

Teeth and Gums

Breast + Nipples

Heart

CST if needed

Abdomen - uterine size and fetal heart if indicated

Urinalysis - protein and glucose

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16
Q

Diagnosis of GDM?

A

Fasting glucose >= 5.5

OGTT 2 hours > 8

DO NOT USE HBA1C

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17
Q

How to do the OGTT in pregs?

A

75g OGTT

fast 8-12 hours overnight

start before 9:30am

drink glucose drink wihtin 5min, remain seated througout 2 hour period

use metoclopramide if vomit

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18
Q

Follow-up following diagnosis of GDM?

A

conduct OGTT 2 hour test - 6-12 weeks post-partum

if normal - HbA1c every 3 years

if HbA1c >6 → further investigation and advice before next pregnancy

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19
Q

Risks to infant with GDM?

A

congential abnormalities

preterm birth

perinatal asphyxia

macrosomia****

resp distress

hypoglycaemia

hypocalcaemia

polycythaemia**

Low iron stores

hyperbilirubinaemia

transient hypertrophic cardiomyopathy

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20
Q

6 week - Postnatal Consultation

A

Enquire about vaginal discharge (lochia) and whether ceased

Ask about healing of the perineum if vaginal delivery

Review abdomen (uterus should be impalpable) and Caesarean Wound if present

Check for any urinary or bowel problems (incontinence)

Check if breast-feeding and whether there are concerns - Breastfeeding

Check if intercourse has resumed and whether there are problems or concerns

Discuss contraception options - Contraception

Advise on post-natal exercises

Adequate diet, rest and personal care, sleep, exercise

Psychological Health - Edinburgh Post-Natal Depression Scale (Post-Natal Depression (PND)), social supports

Consider Pelvic Examination - checking perineum and pelvic floor strengths

Cervical Screening Test (if due) - Cervical Cancer + Screening

Review antenatal screening tests for follow-up action - rubella booster

Other → smoking and alcohol

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21
Q

ABCDE Rule for Melanoma Diagnosis

A

A → Asymmetry → one half different from the other

B → Border → usually irregular

C → Colour → varies within the lesion. pigment is largely or completely absent in hypomelanotic melanoma

D → Diameter → greater than 6mm, sometimes melanomas are diagnosed when smaller than this - an increasing diameter is more important than size

E → Evolution → changing or evolving

22
Q

Mx of melanoma

A

Excisional Biopsy with 2 mm lateral margin and as deep as the subcutaenous fat

23
Q

Main Parameter for Melanoma Prognosis?

A

BRESLOW THICKNESS

24
Q

If complete excision following initial excisional biopsy of melanoma - what are the next steps? what is incomplete excision?

A

If histology confirms melanoma → will need definitive wide local excision.

if initial excision removed all the lesion - WLE should take place within 4 weeks.

if some lesion was left behind after first excision → WLE should take place ASAP.

Margins of the WLE depend on the tumour thickness

25
Management of Subungal Haematoma
Trephination → only perform in \<48hours after 48hours - most haematomas have clotted and trephination is typically not effective
26
Characteristics of Superficial Spreading Melanoma
Larger size than most moles: \> 6 mm and often 1–2 centimetres in diameter at diagnosis Irregular shape Variable pigmentation: colours may include light brown, dark brown, black, blue, grey, pink and red There may be skip areas, which are skin coloured, or white scars due to regression Smooth surface at first, later becoming thicker with an irregular surface that may be dry or warty.
27
EFG Rule in context of Melanoma
Elevated Firm Growing for NODULAR MELANOMA
28
Clinical Features of SCC
Can appear suddenly, grow rapidly OR grow slowly over weeks to months tender and painful on sun exposed sites raised scaly lump common in those who are immunosuppressed
29
Mnaagement of SCC
Need biopsy to establish diagnosis - margin 3-5mm ## Footnote review every 6 months for skin check for at least 2 years after excision
30
Worrying features of a cutaenous horn?
Pain Large Size Induration at the Base Anatomic Site → Nose, Ears, Backs of Hands, Scalp, Forearms, Face and Penis Wide base or low height to base ratio Redness at the base of the horn base Lack of terrace formation - rapid unorganised growth
31
Treatment of Bowen's DIsease. COnsiderations.
Biopsy - but can use topical therapy or photodynamic therapy in regions where the skin heals poorly. Cannot use topical therapies if the disease has extended into the hair follicles Imiquimod 5% topically, at night 5 times weekly for up to 6 weeks. Fluorouracil 5% cream topically, once daily for 3-4 weeks Photodynamic Therapy
32
History of Fitness to Drive in diabetic.
Driving History → accidents and pattern of driving How often pt gets lost Diabetes Recent Hypoglycaemic Episodes Compliance with Medications Hypoglycaemic Aareness History of Syncopal Episodes Signs of CVA Sleep Disorders Insight into dementia if present
33
Examination findings in Fitness to Drive
Visual Examination - visual acuity, visual fields Co-ordination, Balance, Mobility Peripheral Neuropathy Hearing Assessment of Impairment
34
Other means to assess fitness to drive other than history and examination of the patient.
Collateral History regarding driving history Geriatric Assessment for Capacity Occupational Therapist for Driving Assessment Anonymous enquiry from Driving Licensing Authority about the requirements
35
Next steps of management if patient is deemed not safe to drive?
advice patient that he is not able to drive advise him to inform the drivers license authority notify the NOK that pt is not fit to drive Offer assistance and support to look for alternate transport options document the discussions in detail in medical records
36
Presentation of Optic Neuritis. Assocaited condition?
Associated with Multiple Sclerosis Monoocular, visual loss + Eye pain can be with central scotoma commonly also can have photpsias → flickering or falshes of light sudden - hours to days - peaking within 1-2 weeks Fundoscopy - 2/3 is normal. inflammation has retrobulbar neuritis
37
Associated conditions of uveitis?
Ankylosing Spondylitis Inflammatory Bowel Disease (IBD) Behcet Syndrome
38
Mnaagement points for allergic conjunctivitis - nonpharm and pharm
NonPharm - do not rub eyes, no contact lenses, cool compresses, Management → anti-histamine + mast-cell stabiliser Azelastine Eye Drops or Ketotifen or Olopatadine - Patanol 2nd line -\>. Antihistamine only or Mast-Cell only
39
Clinical Features and Management of Episcleritis?
NO BLOOD OUTSIDE THE VESSEL Localised area of congestion minimal discomfort, minimal pain, nil impact on vision, unilateral Associated with autoimmunse RA - Rheumatoid Arthritis (RA) IBD SLE Management self-resolving can trial topical NSAIDS
40
Difference between scleritis and episcleritis?
severe pain differentiates between episcleritis and scleritis also presents with photophobia, deep-red or purplish scleral hue
41
Management of Herpes Keratitis?
Immediate referral to ophthalmology\*\*\* Topical Antiviral Therapy → aciclovir 3% eye ointment 5 times daily for 10-14 days or at least 3 days after healing whichever is shorter Oral antiviral therapy → valaciclovir 500mg po BD for 7-10 days
42
Management of Flash Burn?
Pain Relief Topical ABx NO need for topical anaesthetic NO need for eye patching
43
Management of Hyphaema?
Eye Patch Bed Rest with 30 degree head elevation Dilate pupil for examination and pain Relief Control Nausea and Vomiting Topical Pain Relief Referral to Ophthalmologist
44
Clinical Features + Fundoscopy of Retinal Artery Occlusion vs Retinal Vein Occlusion?
Artery - Cherry Red Spot + Pale Retina Vein - Sunset Storm
45
Fundoscopy Findings of Diabetic Retinopathy?
Non-Proliferative -\> microaneurysms, cotton wool spots, tortuous vessels, exudates Proliferative -\> neovascularisation around the optic disc or retina
46
Clinical Feature of Retinal Detachement?
Pain Loss of Vision Recent history of flashes and floaters presence of dark shadow or curtain moving over the visual field
47
Clinical Features of Macular Degeneration?
Sudden fading central vision Distortion of Vision Straight lines may seem wavy and objects distorted - Amsler Chart Central Vision eventually completely lost Peripheral Fields normal
48
Risk Factors for Cataracts?
Older Age Smoking Alcohol Consumption Sunlight Exposure Lower Educational Status Occur prematurely in people with diabetes Systemic Corticosteroids
49
Clinical Features of Bacterial Keratitis?
95% of contact lens infections Red Eye Reduced visual acuity Pain Eyelid Swelling Photophobia Corneal Epithlial Defect
50