28/11/21 Flashcards
When PEP is indicated, how long after exposure can PEP be prescribed and started?
When PEP is recommended → should be prescribed and started as soon as possible after exposure and within 72 hours. After 72 hours, it should generally NOT be prescribed.
Management points for Gonorrhoea (7 points)
- ABx Therapy - as below
- No sexual contact for 7 days after treatment is administered
- No sex with partners for the last 2 months until partners have been tested and treated as necessary
- Contact Tracing - 2 months
- IUD can stay in place
- Review in 1 week - assess symptoms,
- Test of Cure → at 2 weeks with PCR swab (pharyngeal, anal or cervical NOT urethral)
- Retest in 3 months after exposure
Specific ABX therapy for Gonorrhoea. Genital or Anorectal vs Pharyngeal.
- Anorectal and Genital
- Ceftriaxone 500mg in 2ml of 1% lidocaine IM or 500mg IV Stat
- PLUS Azithromycin 1g PO Stat
- Pharyngeal
- Ceftriaxone 500mg in 2ml of 1% lidocaine IM or 500mg IV Stat
- PLUS Azithromycin 2g PO with food Stat
Symptoms in a male with gonorrhoea
- Urethral Discharge
- Dysuria
- Ano-Rectal Symptoms: Pain on defecation, irritation, Discharge, Disturbed bowel function
- Conjunctivitis: purulent, sight threatening
Symptoms in a female with gonorrhoea
- Vaginal Discharge
- Dypareunia with cervicitis
- Ano-Rectal Symptoms: Pain on defecation, irritation, Discharge, Disturbed bowel function
- Conjunctivitis: purulent, sight threatening
Testing for males with gonorrhoea. MSM for males.
- FPU for NAAT → collect even if asymptomatic (no discharge)
- in MSM → collect pharyngeal and anorectal swabs as well
- Urethral Swab for Culture → if discharge or other local symptoms present
Discharge medications following AMI? principles.
Anti-platelet Therapy
Statin
Beta-Blocker
ACEi
Discharge medications following AMI specific dosing + duration: Anti-platelet therapy.
- Aspirin 100-150mg/day - continue indefinitely
2. Clopidogrel - for 12 months
Discharge medications following AMI specific dosing + duration: Statin
- Statin, highest tolerated dose - continue indefinitely
- atorvastatin 40-80mg PO daily
Discharge medications following AMI specific dosing + duration: beta-blocker. options aplenty.
Beta-Blocker (vasodilatory) in patients with reduced LV systolic function (LV ≤ 40%)
- for stable patients → atenolol 25-100mg PO daily or metoprolol tartate 25-100mg PO BD - if stable with preserved LV function → consider ceasing beta-blocker at 12 months
Heart Failure
- bisoprolol 1.25mg PO daily → increasing to max 10mg daily - nebivolol 1.25mg PO daily → increasing to max 10mg daily - carvedilol <85kg: 3.125mg PO BD → max of 25mg BD, >85kg: 3.125mg PO BD → max of 50mg PO BD - metoprolol succinate MR 23.75mg PO daily → increasing to 190mg PO Daily
Discharge medications following AMI specific dosing + duration: ACEi
perindopril arginine 2.5mg PO daily → increasing to 10mg daily
Continue ACEi long-term
Management of SCC. (3 points)
- Treatment is Surgical Excision with 3-5mm margin
- Radiotherapy can be used when surgery is likely to produce severe scarring or unsuitable (for an elderly or infirm patient)
- Review patients with a primary SCC every 6 months for at least 2 years after excision → look for signs of secondary tumours at each visit
Management of Keratoacanthoma 2 points
- Surgical Excision → 3-5mm margin
- difficult to distinguish between a keratoacanthoma and an SCC on clinical diagnosis or partial biopsies
For Low Severity CAP, if no improvement after 48/24 -> what is the next step for ABx?
- amoxicillin 1g PO TDS
- AND doxycycline 100mg PO BD
Red Flags for admission for hosptial for CAP (7 points)
- Tachypnoea → RR >22 resp/minute
- Heart Rate → HR >100bpm
- Hypotension → systolic BP <90mmHg
- Acute Onset Confusion
- O2<92% on RA
- Multilobar Involvement on CXR
- Blood Lactate Concentration >2mmol/L