51. Chronic pain

Question 1

Pain fibers and location

Answer 1

A delta
C
Ant horn - med/lat ST track - med/lat thalamus - somatosensory cortex

Question 2

Opioids MoA

Answer 2

Mu, delta, Kappa receptors
G protein. Decrease Ca, CAMP, increase K

Question 3

Opiates lambda receptors
action 4

Answer 3

Sedation, Nausea, Resp depression, constipation

Question 4

Kappa receptors

Answer 4

Dysphoria, diuresis, sedation

Question 5

COX 1 vs COX2

Answer 5

COX 1 Gastric protection / platelet function
COX 2 Pain Fever Bone formation

Question 6

What receptor Naloxone blocks

Answer 6

All of them, mu, kappa and lambda