18. Pharmacolgy

Question 1

Therapeutic index

Answer 1

LD50 / ED50

Question 2

Highest and lowest context half life

Answer 2

Highest Thiopental
Lowest propofol

Question 3

Context half life in opiates

Answer 3

After 140 min. F > Alof >Suf > Remi
B4 140 min Alof > F > S > Remi

Question 4

C50. Definition and in opiates

Answer 4

Concentration producing 50% of the maximum effect
S > F = R > A

Question 5

Clearance is independent of

Answer 5

Concentration of the drug

Question 6

Volume of distrubution

Answer 6

Bolus / concentration in blood

Question 7

Extraction ratio conected to liver blood flow

Answer 7

In ER is low, no affected by liver flow
If ER is high, it is affected

Question 8

0 order K vs 1 order

Answer 8

0 constant
1 variable until exhaustion (turn into 0)

Question 9

Potency of opiates

Answer 9

S > R = F > A

Question 10

Opiates and BZP interaction

Answer 10

Synergistic

Question 11

Propofol weight for induction and maintenance

Answer 11

For induction LBW
For maintenance TBW

Question 12

Fat tissue and vapors

Answer 12

Adipose tissue accumulates it slowly, takes until 30 hours to reach equilibrium

Question 13

Isobole definition

Answer 13

Graft that represents combination of 2 drugs to create a certain effect

Question 14

Fentanyl, order of action

Answer 14

Analgesia > Resp D > Decrease laryngospasm > EEG changes

Question 15

Drugs no metabolized by the liver

Answer 15

Remi, Scoline, Esmolol (plasma)
Panacorium (kidney)