28. Reversal of NMB

Question 1

TOF < 0.9 More specific and more sensible

Answer 1

Sensitivity general weakness. 0.35
Specificity. Handgrip. 0.89

Question 2

At TOF 0.6 what respiratory values are impaired?
at TOF 0.7?

Answer 2

Vital capacity and inspiratory force
0.7 respiratory impairment is minimal

Question 3

How many percent of Ach reach the NMJ

Answer 3

50% (the rest broken down by Achesterase)

Question 4

Percentage of neostigmine that is eliminated by the kidney

Answer 4

50%

Question 5

Potency of neo/edro/pyrido

Answer 5

Neostigmine > Pyridostigmine > Edrophonium

Question 6

TOF ratio

Answer 6

< 0.9 Pharyngeal dysfunction
TOF 0.8 Blurred vision, difficulty swallowing, jaw weakness
0.7 diplopia, dysarthria, general weakness, facial numbness

Question 7

Sugammadex characteristics

Answer 7

Increase concentration of rocuronium in plasma (moves from extracelular fluid)
Increase PT and PTT with no increase risk of bleeding
Changes the clearance of rocuronium, from liver to renal