13. Respiratory physiology Flashcards
PaO2 in mithochondria
10 mmHg (4-22)
Volume Capacity
End Respiratory Volume + Tidal Volume
Funtional Residual capacity
End respiratory volume + Residual Volume
PaO2 in CO intoxication
PaO2 normal
FRC from standing to lying down
Decrease in one liter
ARDS hypoxemia
Due to shunt
Why hypoxemia in elderly?
Due to increase closing capacity above FRC
Whats closing capacity?
Closing volume + Residual Volume
CaO2 formula
1.34xHbxSat + 0.003xPaO2
Aa gradient
PAO2 - PaO2
PAO2 formula
FiO2 x (760-47) - PCO2/0.8
Changes in methilhemoglobilemia
PaO2 normal
Decrease Sat O2, DO2
Changes in CO poisoning
Shift to the left
Conformational changes in Hb
Anatomic dead space
100 - 150 ml
VD/VT in COPD
Up to 0.9 . Hyperventilation to compensate
Whats the problem in emphysema
Loss of elastic tissue. Issue with expirium
Transpulmonary pressure
Driving force
PAW - PPL
In healthy PAW = 0
Resistance of the respiratory system
Increase in large airways
Turbulent
Smaller lung volume, Higher resistance
O2 content minimum and maximum
Mith < SVC < IVC < PA
FRC changes
Increase with Age and Height
Decrease in women and fat
Expiratory flow rate in restrictive
Increase
What’s driving pressure
PPL (pleural pressure)
Zone 3 vs zone 4 blood flow
Lower in zone 4 due to compression on vessels