12. Neuromuscular physiology / Pharmacology

Question 1

Motor neuron pathway

Answer 1

From ventral horn to NMJ

Question 2

What are MEPP (miniature end plate potentials)

Answer 2

Created by quanta
1/100 amplitude
Uniformly packed. In the absence of a stimulus
AP - Release of several quanta (200 of 5000 molecules each)

Question 3

Ca function

Answer 3

Enters and produces depolarization release of ACh
Recovers AP with K
Ca 2x vs quanta 16x

Question 4

Inhibition of Ach release by

Answer 4

HypoCa HyperMg

Question 5

Downregulation. causes, effects on NMBA

Answer 5

Organophosphates. pyridostigmine. (decrease ACh esterases)
MG decreases ACh receptors
Effects. Increase sensitivity to Non-D. Decrease resistance to Scoline

Question 6

Effect of burns in NMBA

Answer 6

Decrease sensitivity in non-D

Question 7

Duration of duration of ACh

Answer 7

1 ms

Question 8

Eaton Lambert D

Answer 8

Disease of voltage P Ca channels

Question 9

Scoline degradation

Answer 9

In plasma

Question 10

Botulinium MoA

Answer 10

Prevents release of ACh from presynaptic vesicles

Question 11

Mg on NMBA

Answer 11

Amplifies muscle relaxation

Question 12

Ach R location

Answer 12

In the upper part of the folds

Question 13

Receptors in adults

Answer 13

Alpha 1 alpha 1 beta lambda Epsilon

Question 14

Reason for post tetanic potentiation after NMDR

Answer 14

Accumulation of calcium release from the presynaptic