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Miller's Anesthesia > 50. Coagulation > Flashcards

50. Coagulation Flashcards

1
Q

Virchow triad

A

Venous stasis, hypercoagulopathy, endothelial lesion of blood vessels

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2
Q

Most common inherited prothrombotic condition

A

Factor V Leiden deficiency
Inability of APC to degradation of factor 5a

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3
Q

aPTT pathway and most imp factors

A

Intrinsic. 8 9

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4
Q

PT pathway and more important factor

A

Extrinsic. most imp 7

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5
Q

Vitamin K dependent factors

A

2 7 9 10 PC PS

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6
Q

vW disease

A

most common
Qualitative / quantitative deficiency
For mild cases DDAVP
PT . aPTT long
In severe cases reductions in factor 8

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7
Q

Hemophilia types

A

A 8
B 9
C 11

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8
Q

HIT

A

Mild / mod thrombocytopenia
venous arterial thrombosis
Tx. Angiomax (bivalirudin)
Dx. Serotonin release essay

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9
Q

Factors produce by the liver

A

fibrinogen, prothrombin, factor V, VII, IX, X, XI, XII, as well as protein C and S, and antithrombin

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10
Q

DIC MoA

A

Activation of factor 7 / 7a

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11
Q

Stop anticoagulants for neuroaxial

A

Clopid 7d
Warf 5 d + INR < 1.5
Dabigatran 5d
Tioclodipine 14d

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12
Q

Coagulation pathway

A
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13
Q

CD39

A

Adenosine diphosphate.
platelet inactivator (like NO prostaglandin 1)

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14
Q

Bernard Soulier syndrome

A

Absence of glycoprotein 1b, factor 9, f5 receptors

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15
Q

More important enzyme for regulation of hemostasis

A

thrombin (2a)

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16
Q

Protein C action

A

Breakdown of factor 8a and 5a

17
Q

Chronic liver disease and coagulation

A

No changes in coagulation

18
Q

Trauma induced coagulopathy

A

Due to activated protein C

19
Q

COX 1 vs COX 2

A
  1. Ptl, kidney, gastro
  2. Pain and fever, bone formation
20
Q

Reversible P2Y12

A

Ticagrelor cangrelor
Ticlopidine, clopidogrel pasugrel no

21
Q

Longest and shortest half life of factors

A

Longest factor 2 (60h)
Shortest factor 7, PC 3-6h

22
Q

Warfarin half life and effect time

A

40 hours
complete effect 3-4 days

23
Q

Protamine and LMWH

A

Partially reverse (requieres molecules with more than 14 saccharides)

24
Q

Contraindication for thrombolysis

A
25
Q

Reverse of warfarin

A

Prothrombin complex concentrate + VK

26
Q

Reverse of Rivaroxaban (xarelto)

A

Andexanet alpha

Miller's Anesthesia (43 decks)

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