5- Biological Basis of Nervous System Disorders

Question 1

Schizophrenia

Answer 1

• dopamine hypothesis - too much
• mania is too much ser and NorEpi
• birth trauma/hypoxemia
• excessive marijuana in adolescence
• partially inherited
• treated w/ !!! neuroleptics/antipsychotic - block dopamine receptors

Question 2

Depressive

Answer 2

• decreased serotonin, dopamine, norepi
• mania is too much ser and NorEpi
• monoamine theory for depression/mania
• partial family linkage
• high cortisol, hippocampal atrophy, high glucose in amygdala/emotion
• MS/bipolar= more at risk of bipolar = genetic risk

Question 3

Alzheimers

Answer 3

• ACh loss = less enzyme ChAT choline acetyltransferase which makes ACh
• B-amyloid plaques
• neurofibrillary tangles

Question 4

Parkinson’s

Answer 4

• low dopamine productino in substantia nigra, which is part of basal ganglia
  treatment: L-DOPA = precursor of dopamine- converted to dopamine when reaches brain
• bradykinesia = slow movement
• resting tremor - when not using
• pill-rolling tremors
• masklike faces - no expression
• cogwheel rigidity- muscle tension stops movement
• shuffling gait