3p toxi: GASES ASFIXIANTES (CO2 & cianuro) Flashcards

1
Q

⭐️toxicocinetica del CO2

A

afinidad x240 veces + q el O2
*al unirse a HB forma: carboxiHB

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2
Q

⭐️ a q otras sust tambn se una el CO2 aparte de la Hb

A
  • mioglobina
  • citocromo oxidasa
  • NADPH reductasa
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3
Q

⭐️hay cianosis en intox x CO2
v o f

A

FALSO
xq si hay O2 en sangre solo q esta desplazado por el CO2 y eso provoca HIPOXIATISULAR

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4
Q

⭐️Signo caract de la intox x CO2
a)resp de kussmaul
b)olor a ajo
c)hemolisis
d)respiracion de cheyene stokes

A

RESP DE CHEYENE STROKES
*periodos de apnea —> aumeto progresivo de respiracion —> apnea

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5
Q

complicacion + frecuente intox x co2

A
  • RABDOMIOLISIS
  • secuelas neurologicas
  • cadaver color cereza
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6
Q

⭐️dx intox x co2

A
  • HC
  • cooximetria HbCO
  • gases arteriales: AC METABOLICA & RESP
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7
Q

⭐️Tx de intox x co2

A

OXIGENO AL 100%

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8
Q

⭐️SIGNO caracteristico de la intox x cianuro
a)olor a ajo acido
b)olor a almendras amargas
c) vomito lechoso

A

-OLOR A ALMENDRAS AMARGAS

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9
Q

⭐️tCINETICA de la intox x cianuro

A

se une a ezimas mitocondriales como COMPLEJO CITOCROMO OXIDASA & bloquea ultimo paso FOSFORILACION OXIDATIVA

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10
Q

⭐️dx intox x cianuro

A

CC:
- ac. metabolica
- deshidrogenasa lactica
-concentr. cianuro en sangre
-tiocinato en orina

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11
Q

⭐️tx de la intox x cianuro

A

1- HIDROXICOBALAMINA (B12)
2- CIANO KIT
#1 nitrito de amilo (inhalado)
#2 nitrito de Na (iv)
#3 tiosulfato de Na (iv)
✨RECORDAR LA VIA DE ELIMINACION NATURAL DEL CIANURO

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