33: Renal Pathology 4

Question 1

four parts of the glomerular tuft

Answer 1

1. parietal ep
2. visceral ep (podocytes)
3. fenestrated endothelium
4. mesangial cells

Question 2

what are crescents made of?

Answer 2

epithelial cells + infiltrating leukocytes

Question 3

what causes hyalinosis

Answer 3

endothelial or capillary wall injury

Question 4

sclerosis in the kidneys

Answer 4

deposition of ECM, mostly in the mesangial area

Question 5

what do subepithelial humps indicate?

Answer 5

actue glomerulonephritis

Question 6

what do membranous deposits indicate?

Answer 6

membranous nephropathy

Question 7

what do subendothelial deposits indicate (2 things)

Answer 7

lupus nephritis, MPGN

Question 8

what do mesangial deposits indicate?

Answer 8

IgA nephropathy

Question 9

in nephrotic syndrome, what is the protein lost in the largest proportion?

Answer 9

albumin

Question 10

three most frequent systemic causes related to nephrotic syndrome

Answer 10

SLE, DM, amyloidosis

Question 11

biomarker DNAJB9 indicates what?

Answer 11

Fibrilary glomerulonephritis

Question 12

fibrillary glomerulonephritis presentation

Answer 12

hematuria, nephrotic syndrome, progressive renal insufficiency

Question 13

histo of fibrillary glomerulonephritis

Answer 13

fibrillary deposits in mesangium that resemble amyloid but does not stain with Congo red