33: Renal Pathology 1

Question 1

major cause of glomerular kidney disease vs interstitial and tubular kidney diseases

Answer 1

glomerular: immune mediated

interstitial and tubular: toxin/infection

Question 2

three parts of the filtration barrier of the glomerulus

Answer 2

1. cap endothelium
2. BM
3. foot processes of podocytes

Question 3

what are glomeruli freely permeable to?

Answer 3

water, small solutes, small proteins

Question 4

what charge of protein cant get thru glomeruli and why

Answer 4

negatively charged - bc the endothelial cells are negatively charge and repel these

Question 5

three hormones secreted by kidneys

Answer 5

EPO, renin, prostaglandins

Question 6

azotemia

Answer 6

elevation of BUN and Cr, related to decreased GFR

Question 7

uremia

Answer 7

azotemia + symptoms

Question 8

symptoms of uremia

Answer 8

cognitive dysfunction, SOA, fatigue, loss of appetite, muscle cramps, N/V, itching, unexplained WL, metallic taste in mouth

Question 9

BUN stands for?

Answer 9

blood urea nitrogen

Question 10

ideal BUN:Cr ratio

Answer 10

between 10:1 and 20:1

Question 11

normal GFR

Answer 11

90 or higher