[33] Pharma III Anti-Arrhthmics and Angina

Question 1

What route is Nitroglycerin taken in?

Answer 1

Sublingual Route

Question 2

Drug of Choice for Vasospastic Diseases

Answer 2

Nitrates and CCBs

Question 3

Oral Bioavailability of Nitroglycerin

Answer 3

10-20%

Question 4

Duration of Effect of Nitroglycerin

Answer 4

15-30 Minutes

Question 5

Main problem with Nitrates

Answer 5

Tolerance

Question 6

What interval should you take Nitroglycerin in?

Answer 6

8-16-24 Hour

Question 7

At low concentrations of nitrates what responds?

Answer 7

Veins

Question 8

At slightly higher than the low concentration of nitrates what responds?

Answer 8

Arteries

Question 9

Mechanism of Action of Nitrates

Answer 9

Decreased Preload
Increased Venous Compliance

that HAS A SIDE EFFECT of

Dilating Coronary Arteries

(The first two points are the main way it works)

Question 10

1 Side Effect of Nitrates

Answer 10

Headache

Question 11

Drug for Supraventricular Tachycardia

Answer 11

Diltiazem

Verapamil

Question 12

1 Side Effect of Old Generation CCBs

Give an example

Answer 12

Reflex Tachycardia

Nifedipine

Question 13

Contraindications for Short-Acting CCBs

Answer 13

Unstable Angina

Question 14

Why would you give someone very tiny physiologic amounts of Beta Blockers?

Answer 14

Allow transcription to upregulate receptors to allow adrenergic stimulation again

Question 15

Latest Beta Blocking Drug

Answer 15

Nebivolol

Question 16

Mechanism of Action of Ivabradine

Answer 16

If Inhibitor

Question 17

What Phase of Contraction is equivalent to the QRS complex?

Answer 17

Phase 0

Question 18

Do fast or slow Potassium channels open first?

Answer 18

Slow followed by a rapid fast Potassium extrusion

Question 19

Can SA and AV nodes be affected by Na Channel Blockers?

Answer 19

No, because they use calcium channels

Question 20

How do you delay Phase 4 Depolarization?

Answer 20

Potassium Channel Blockers

Question 21

[Vaughan-Williams Classification]

Class I

Answer 21

Na Channel Blockers

Question 22

[Vaughan-Williams Classification]

Class II

Answer 22

Beta-Blockers

Question 23

[Vaughan-Williams Classification]

Class III

Answer 23

Potassium Channel Blockers

Question 24

[Vaughan-Williams Classification]

Class IV

Answer 24

Calcium Channel Blockers

Question 25

[Vaughan-Williams Classification] Function: Class IA

Answer 25

Prolongs Action Potential Duration

Question 26

[Vaughan-Williams Classification] Function: Class IB

Answer 26

Shortens Action Potential Duration

Question 27

[Vaughan-Williams Classification] Function: Class IC

Answer 27

Minimal Action Potential Effects

Question 28

Examples of Class IA Drugs

Answer 28

Quinidine Procainamide Disopyramide

Question 29

Examples of Class IB Drugs

Answer 29

Mexiletine Lidocaine Tocainide

Question 30

Examples of Class IC Drugs

Answer 30

Flecainide Moricizine Propafenone

Question 31

Sodium Channel Blockers Block Which Phase?

Answer 31

Phase 0

Question 32

[Potency for Sodium Channel Blockade] Class IA Class IB Class IC

Answer 32

A: Moderate B: Minimal C: Marked C > A > B

Question 33

Amiodarone Blocks Which Channels

Answer 33

Calcium Beta Sodium

Question 34

Effect of Adrenergic Receptor Agonists on Potassium Channels

Answer 34

Stimulation of opening of K Channels causing Hyperpolarization

Question 35

What do you give to patients with Atrial Flutter or Fibrillation

Answer 35

Class 1A Sodium Channel Blockers

Question 36

What drug toxicity can cause Torsades de Pointes

Answer 36

Class 1A Sodium Channel Blockers

Question 37

What drug toxicity causes Cinchonism?

Answer 37

Quinidine

Question 38

Effect on Quinidine on Digoxin

Answer 38

Raises the levels

Question 39

What drug can cause REVERSIBLE Lupus-Like Syndrome

Answer 39

Procainamide | Hydralazine also causes SLE Symptoms but I don't know if it's reversible

Question 40

Major Metabolite of Procainamide

Answer 40

NAPA | N-Acetylprocainamide

Question 41

Examples of Class III Drugs

Answer 41

``` Amiodarone Bretylium Sotalol Dofetilide Ibutilide ```

Question 42

Classes of Drugs that Prolong Action Potential?

Answer 42

Class 1A | Class III

Question 43

Pulmonary Fibrosis can result as a toxicity of which drug?

Answer 43

Amiodarone

Question 44

Mechanism of Action of Adenosine

Answer 44

Opens K Channels | Inhibits Ca Channels

Question 45

Half Life Adenosine

Answer 45

10 Seconds