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[OS 213] CVS Module > [33] Pharma III Anti-Arrhthmics and Angina > Flashcards

[33] Pharma III Anti-Arrhthmics and Angina Flashcards

1
Q

What route is Nitroglycerin taken in?

A

Sublingual Route

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2
Q

Drug of Choice for Vasospastic Diseases

A

Nitrates and CCBs

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3
Q

Oral Bioavailability of Nitroglycerin

A

10-20%

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4
Q

Duration of Effect of Nitroglycerin

A

15-30 Minutes

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5
Q

Main problem with Nitrates

A

Tolerance

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6
Q

What interval should you take Nitroglycerin in?

A

8-16-24 Hour

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7
Q

At low concentrations of nitrates what responds?

A

Veins

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8
Q

At slightly higher than the low concentration of nitrates what responds?

A

Arteries

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9
Q

Mechanism of Action of Nitrates

A

Decreased Preload
Increased Venous Compliance

that HAS A SIDE EFFECT of

Dilating Coronary Arteries

(The first two points are the main way it works)

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10
Q

1 Side Effect of Nitrates

A

Headache

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11
Q

Drug for Supraventricular Tachycardia

A

Diltiazem

Verapamil

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12
Q

1 Side Effect of Old Generation CCBs

Give an example

A

Reflex Tachycardia

Nifedipine

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13
Q

Contraindications for Short-Acting CCBs

A

Unstable Angina

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14
Q

Why would you give someone very tiny physiologic amounts of Beta Blockers?

A

Allow transcription to upregulate receptors to allow adrenergic stimulation again

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15
Q

Latest Beta Blocking Drug

A

Nebivolol

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16
Q

Mechanism of Action of Ivabradine

A

If Inhibitor

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17
Q

What Phase of Contraction is equivalent to the QRS complex?

A

Phase 0

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18
Q

Do fast or slow Potassium channels open first?

A

Slow followed by a rapid fast Potassium extrusion

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19
Q

Can SA and AV nodes be affected by Na Channel Blockers?

A

No, because they use calcium channels

20
Q

How do you delay Phase 4 Depolarization?

A

Potassium Channel Blockers

21
Q

[Vaughan-Williams Classification]

Class I

A

Na Channel Blockers

22
Q

[Vaughan-Williams Classification]

Class II

A

Beta-Blockers

23
Q

[Vaughan-Williams Classification]

Class III

A

Potassium Channel Blockers

24
Q

[Vaughan-Williams Classification]

Class IV

A

Calcium Channel Blockers

25
Q

[Vaughan-Williams Classification]

Function: Class IA

A

Prolongs Action Potential Duration

26
Q

[Vaughan-Williams Classification]

Function: Class IB

A

Shortens Action Potential Duration

27
Q

[Vaughan-Williams Classification]

Function: Class IC

A

Minimal Action Potential Effects

28
Q

Examples of Class IA Drugs

A

Quinidine
Procainamide
Disopyramide

29
Q

Examples of Class IB Drugs

A

Mexiletine
Lidocaine
Tocainide

30
Q

Examples of Class IC Drugs

A

Flecainide
Moricizine
Propafenone

31
Q

Sodium Channel Blockers Block Which Phase?

A

Phase 0

32
Q

[Potency for Sodium Channel Blockade]

Class IA
Class IB
Class IC

A

A: Moderate

B: Minimal

C: Marked

C > A > B

33
Q

Amiodarone Blocks Which Channels

A

Calcium
Beta
Sodium

34
Q

Effect of Adrenergic Receptor Agonists on Potassium Channels

A

Stimulation of opening of K Channels causing Hyperpolarization

35
Q

What do you give to patients with Atrial Flutter or Fibrillation

A

Class 1A Sodium Channel Blockers

36
Q

What drug toxicity can cause Torsades de Pointes

A

Class 1A Sodium Channel Blockers

37
Q

What drug toxicity causes Cinchonism?

A

Quinidine

38
Q

Effect on Quinidine on Digoxin

A

Raises the levels

39
Q

What drug can cause REVERSIBLE Lupus-Like Syndrome

A

Procainamide

Hydralazine also causes SLE Symptoms but I don’t know if it’s reversible

40
Q

Major Metabolite of Procainamide

A

NAPA

N-Acetylprocainamide

41
Q

Examples of Class III Drugs

A 
Amiodarone
Bretylium
Sotalol
Dofetilide
Ibutilide
42
Q

Classes of Drugs that Prolong Action Potential?

A

Class 1A

Class III

43
Q

Pulmonary Fibrosis can result as a toxicity of which drug?

A

Amiodarone

44
Q

Mechanism of Action of Adenosine

A

Opens K Channels

Inhibits Ca Channels

45
Q

Half Life Adenosine

A

10 Seconds

[OS 213] CVS Module (33 decks)

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