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[OS 213] CVS Module > [30] Pharma II Anti-Thrombotics > Flashcards

[30] Pharma II Anti-Thrombotics Flashcards

1
Q

Contraindications for Beta Blockers

A

Hypotension
Bradycardia
Asthma
LV Dysfunction

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2
Q

What can you give to prevent remodeling of the Left Ventricle

A

ACE Inhibitors

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3
Q

What do you give to reduce the risk of recurrent coronary artery thrombosis

A

Antiplatelet Therapy

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4
Q

Statin therapy should be started at a low dose or high dose?

A

High Dose

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5
Q

Heparins biologic activity is dependent on?

A

Antithrombin

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6
Q

Difference of LMWH compared to Unfractionated Heparin

A

Heparin inhibits: Thrombin, IXa and Xa

LMWH inhibits: Thrombin alone

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7
Q

Anti-Platelet Therapy commonly uses this drug

A

Aspirin

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8
Q

How should you take an Aspirin tablet?

A

Chewed or crushed quickly

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9
Q

[Bivalirudin]

Clinical Use

A

Heparin alternative in PCI patients

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10
Q

[Coumarin]

Clinical Use

A

Treatment of embolism, DVT, AF

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11
Q

[Coumarin]

Mechanism of Action

A

Inhibits synthesis of factors II, VII, IX, and X

Inhibits production of Vitamin K

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12
Q

[Coumarin]

Contraindications

A

Hemophilia

Pregnancy

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13
Q

[Coumarin]

Overdose Treatment

A

Vitamin K

Phytonadione

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14
Q

An ideal fibrinolytic agent with a short half life that is recommended in the West

A

Alteplase

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15
Q

Inhibitors of Fibrinolysis

A

Aminocaproic Acid
Tranexamic Acid
Aprotinin

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16
Q

Mechanism of Action of Aminocaproic Acid

A

Competitive lysine inhibitor

17
Q

Mechanism of Action of Aprotinin

A

Serine protease inhibitor

18
Q

Examples of Direct Thrombin Inhibitors that bind to both catalytic sites and substrate recognition site

A

Hirudin

Bivalirudin

19
Q

Small molecules that bind only at the thrombin active site

A

Argatroban

Melagatran

20
Q

In case of Heparin Overdose you give?

A

Protamine Sulfate

21
Q

Mechanism of Action of Aspirin

A

Irreversible Cyclooxygenase Inhibitor

Specifically prevents the creation of Thromboxane A2

22
Q

Mechanism of Action of Dipyridamole

A

Lower platelet calcium

Increases cAMP formation

[OS 213] CVS Module (33 decks)

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