[30] Pharma II Anti-Thrombotics Flashcards
Contraindications for Beta Blockers
Hypotension
Bradycardia
Asthma
LV Dysfunction
What can you give to prevent remodeling of the Left Ventricle
ACE Inhibitors
What do you give to reduce the risk of recurrent coronary artery thrombosis
Antiplatelet Therapy
Statin therapy should be started at a low dose or high dose?
High Dose
Heparins biologic activity is dependent on?
Antithrombin
Difference of LMWH compared to Unfractionated Heparin
Heparin inhibits: Thrombin, IXa and Xa
LMWH inhibits: Thrombin alone
Anti-Platelet Therapy commonly uses this drug
Aspirin
How should you take an Aspirin tablet?
Chewed or crushed quickly
[Bivalirudin]
Clinical Use
Heparin alternative in PCI patients
[Coumarin]
Clinical Use
Treatment of embolism, DVT, AF
[Coumarin]
Mechanism of Action
Inhibits synthesis of factors II, VII, IX, and X
Inhibits production of Vitamin K
[Coumarin]
Contraindications
Hemophilia
Pregnancy
[Coumarin]
Overdose Treatment
Vitamin K
Phytonadione
An ideal fibrinolytic agent with a short half life that is recommended in the West
Alteplase
Inhibitors of Fibrinolysis
Aminocaproic Acid
Tranexamic Acid
Aprotinin
Mechanism of Action of Aminocaproic Acid
Competitive lysine inhibitor
Mechanism of Action of Aprotinin
Serine protease inhibitor
Examples of Direct Thrombin Inhibitors that bind to both catalytic sites and substrate recognition site
Hirudin
Bivalirudin
Small molecules that bind only at the thrombin active site
Argatroban
Melagatran
In case of Heparin Overdose you give?
Protamine Sulfate
Mechanism of Action of Aspirin
Irreversible Cyclooxygenase Inhibitor
Specifically prevents the creation of Thromboxane A2
Mechanism of Action of Dipyridamole
Lower platelet calcium
Increases cAMP formation
