3 - Interferons Flashcards
Interferon protects the cell from viral infections
True
Interferon are a family of secretory glycoproteins
True
There are 3 types of interferon
True (Type I, II and III)
IFN-alpha and IFN-beta are type I interferon
True
IFN-gamma is the only Type II interferon
True
Type I IFN have multiple biological activities I.e. Antiviral, antiproliferative, antiangiogenic etc
True
IFN-beta has 29% structural similarity to IFN-alpha
True
IFN-gamma does not share any structural homology to IFN-alpha and IFN-beta
True
Pegylated IFN I.e. IFN-alpha increases the time of the IFN in circulation to enable the frequency of dosing to be reduced
True
Pegylation is a process by which polyethylene glycol (PEG) is attached to IFN
True
IFN-alpha and IFN-gamma are excreted renally
True
IFN-alpha and IFN-gamma are metabolised under proteolytic degradation during renal tubular reabsorption (renal metabolism)
True
IFN are not protein bound
True
IFN-alpha has induced the formation of neutralising antibodies
True
Patients with high titres of anti-IFN-alpha neutralising antibodies have decreased response to therapy
True
IFN-alpha and IFN-beta (both Type I IFN) share the same receptor
True
IFN-gamma (Type II IFN) binds to a different receptor to IFN-alpha and IFN-beta (Type I IFN)
True
IFN has antiviral activity
True
IFN has antiproliferative activity
True
IFN has immunoregulatory activity
True