2 - Topical Contact Allergens Flashcards
Topical contact allergens induces an allergic contact dermatitis in a previously unsensitised host
True
Topical contact allergens treat various dermatoses by maintaining the allergic contact dermatitis at the site of the skin disease being treated
True
The ideal contact allergen is a potent contact sensitiser
True
The ideal contact allergen should not be widely found in the environment
True
The ideal contact allergen does not cause significant adverse effects
True
The ideal contact allergen does not cross-sensitise with other substances
True
It is not completely known how topical contact allergens may improve alopecia areata or viral warts
True
The ‘antigenic competition’ theory has been postulated in the mechanism of action of topical contact allergens in alopecia areata, in that an immunoreaction to one antigen may inhibit the development of the immune response to another unrelated antigen
True (the ratio of CD4:CD8 peribulbar T cell infiltrate changes to 1:1 from 4:1 to reflect a relative increase in peribulbar CD8 T cells)
Long term treatment of alopecia areata with topical contact allergens DPCP and SADBE leads to significant non-specific systemic suppression of delayed hypersensitivity reactions
True
DPCP treatment of alopecia areata reduces the abnormal expression of Human Leukocyte Antigen (HLA) in the epithelium of lower hair follicles
True
Long term treatment of alopecia areata with DPCP leads to recovery of hair follicles by driving auto reactive T cells into activation-induced cell death
True
The mechanism of action of topical contact allergens in warts may be a result of a non-specific cell-mediated immune response that triggers virus-infected cell lysis and death
True
Both DPCP and SADBE are non-mutagenic on the Ames test
True (in contrast to DNCB which is mutagenic)
The synthetic precursor of DPCP is a potential contaminant of commercially obtained samples and a potent mutagen
True (although DPCP itself is not a mutagen) - presence of the contaminant may be screened before use and periodically thereafter using liquid chromatography
DPCP is light sensitive
True