29. Flaviviridae Flashcards
MEMBERS OF THE FAMILY FLAVIVIRADE (4 genera)
- Flavivirus
- Hepacivirus
- Pegivirus
- Pestivirus
Which viruses have the following properties:
Virions are spherical, 40-60 nm in diameter, and consist of a tightly adherent lipid envelope covered with indistinct spikes (peplomers) surrounding a spherical nucleocapsid
Genome is a single molecule of linear, +ssRNA, approximately 11 kb (genus 1), 12.3 kb (genus 2), or approximately 9.6 kb (genus 3 and 4) in size; 5’ end capped in 1, but not 2 or 4. Genomic RNA is infectious
Cytoplasmic replication; a single polyprotein is translated from genomic RNA; it is cleaved co- and posttranslationally to yield eight or nine nonstructural proteins and three or four structural proteins
Maturation occurs on intracytoplasmic membranes without evidence of budding
Flavivirus
Genus1 = Flavivirus
Genus 2 = Pestivirus
Genus 3 = hepaciviruses
Genus 4 = pegiviruses
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RESERVOIR HOSTS FOR GENUS PESTIVIRUS (FAM. FLAVIVIRIDAE):
Bovine viral diarrhea virus
Border disease virus
Classical swine fever virus
- Bovine viral diarrhea virus / Cattle, calves / (Contact, congenital) / Mostly inapparent. Congenital disease: generalized persistent infection, mucosal disease / Worldwide
- Border disease virus / Sheep / Congenital disease / Worldwide
- Classical swine fever virus / Swine (Contact) / Systemic disease. Congenital disease / Worldwide, but eradicated in some countries
MEMBERS OF GENUS PESTIVIRUS (Fam. FLAVIVIRIDAE) (3 species)
- Bovine viral diarrhea virus / Cattle, calves (Contact, congenital) / Mostly inapparent. Congenital disease: generalized persistent infection, mucosal disease / Worldwide
- Border disease virus / Sheep / Congenital disease / Worldwide
- Classical swine fever virus / Swine (Contact) / Systemic disease. Congenital disease / Worldwide, but eradicated in some countries
MEMBERS OF THE GENUS FLAVIVIRUS (Fam. FLAVIVIRIDAE):
mosquito-borne flaviviruses (10 species)
- Dengue viruses 1, 2, 3, and 4
- Japanese encephalitis virus
- Murray Valley encephalitis virus
- St. Louis encephalitis virus
- Tembusu virus
- Turkey meningoencephalitis virus
- Usutu virus
- Wesselsbron virus
- West Nile virus
- Yellow fever virus