23. Arenaviridae

Question 2

MEMBERS OF THE FAMILY ARENAVIRIDAE (2 genera)

Answer 2

1. Mammarenavirus with 27 virus species,
2. Reptarenavirus with 3 virus species

Question 3

Which viruses have the following properties:

Virions are pleomorphic, enveloped, generally 110-130nm in size. Virion contains nonfunctional host-cell ribosomes.

Virions contain at least two circular helical nucleocapsids with associated RNA-dependent RNA polymerase (transcriptase). Genome consists of two segments, large (L, 7.2 kb) and small (S, 3.4 kb), of ambi.ss RNA, (both ambisense)

Viral proteins:

• nucleoprotein (N),
• RNA-dependent RNA polymerase (L),
• two glycoproteins (Gp1, Gp2), and
• a zinc-binding matrix protein (Z)

Replication occurs in the cytoplasm; generally noncytocidal; persistent infections

Maturation occurs by budding from the plasma membrane

Genetic reassortment occurs between closely related viruses

Answer 3

Arenaviruses

Question 5

MEMBERS OF THE GENUS MAMMARENAVIRUS (Fam. ARENAVIRIDAE) (3 + 5 species)

Answer 5

1. OLD WORLD ARENAVIRUSES
   
   1. LYMPHOCYTIC CHORIOMENINGITIS VIRUS
   2. LASSA VIRUS
   3. LUJO VIRUS
2. NEW WORLD ARENAVIRUSES
   
   1. JUNIN (ARGENTINE HEMORRHAGIC FEVER) VIRUS
   2. CHAPARE (CHAPARE HEMORRHAGIC FEVER) VIRUS
   3. MACHUPO (BOLIVIAN HEMORRHAGIC FEVER) VIRUS
   4. GUANARITO (VENEZUELAN HEMORRHAGIC FEVER) VIRUS
   5. SABIA´ (BRAZILIAN HEMORRHAGIC FEVER) VIRUS

Question 6

MEMBERS OF THE GENUS REPTARENAVIRUS (Fam. ARENAVIRIDAE) (REPTILE-ASSOCIATED ARENAVIRUSES)

Answer 6

BOID INCLUSION BODY DISEASE - ASSOCIATED VIRUSES (University of Helsinki virus, Golden Gate virus, NL B3 virus, and California Academy of Sciences virus)