19. Filoviridae Flashcards
Which viruses have the following properties:
Virions are pleomorphic, appearing as long filamentous forms and other shapes; they have a uniform diameter of 80 nm and vary greatly in length (unit nucleocapsid lengths of about 800 nm for genera 1 and 1000 nm for genera 2 virus)
Virions are composed of a lipid envelope covered with spikes surrounding a helically wound nucleocapsid
The genome is composed of a single molecule of negative-sense, single-stranded RNA, 19.1 kb in size
Infection is extremely cytopathic in cultured cells and in target organs of host
Cytoplasmic replication, large intracytoplasmic inclusion bodies, budding from the plasma membrane
Filoviruses
genera 1: Margburg
genera 2: Ebola virus
MEMBERS OF THE FAMILY FILOVIRIDAE (3 genera)
Marburgvirus, consisting of a single species Marburg marburgvirus that has two genetically distinct viruses isolated in Kenya, namely Marburg virus and Ravn virus;
Ebolavirus, with five recognized species of Sudan ebolavirus (Sudan virus), Zaire ebolavirus (Ebola virus), Reston ebolavirus (Reston virus), Bundibugyo ebolavirus (Bundibugyo virus), and Taı¨ Forest ebolavirus (Taı¨ Forest virus); and
Cuevavirus that contains a single uncultured virus species Lloviu cuevavirus (Lloviu virus) detected in dead bats in Spain.
