(24) CC Oncology Flashcards
1
Q
(Cancer and the Immune System)
(Evidence of the immune system controlling cancer)
Three things support this
- spontaneous remission of what?
- Increase incidence of cancer in what?
- Presence of what within tumor?
A
- terminal caner
- immunosuppressed
- tumor specific Tc cells
2
Q
- The presence of lymphocytes in certain tumors has been what?
- What three types of tumors especially?
A
- prognostic (Predicting the likely outcome of a disease) - usually a good one
- thymoma, mammary gland tumors, splenic fibrous histiocytic nodules
3
Q
A
4
Q
Cooley inject heat treated S. pyogenes and serratia marcenscens into patients with some success of cancer treatment (got immune system involved)
A
5
Q
1-3. What are the three strategies of immunotherapy for cancer?
A
- Nonspecific immunotherapy
- passive stimulation
- active immune stimulation
6
Q
(Non-specific immunity)
(Goal)
- Engage what arms of the immune system to do what?
- mainly what kinds of cells?
A
- engage innate and adaptive arms; to recognize and attack neoplastic cells
- APCs (dendritic cells/macrophages)
7
Q
(Nonspecific Tumor Immunotherapy)
(BCG-Bacillus Calmette-Guerin)
- developed from what as a vaccine?
- What is the mechanism of action?
- direct contact with what?
- elicits production of what?
- stimulating what?
- what kind of cytotoxicity?
- Whats another name for connective tissue cancer?
A
- M. bovis
- unknown
- tumor cells
- cytokines
- neuts, macs, and T lymphs
- cell mediated
- sarcoids
8
Q
(Nonspecific Tumor Immunotherapy)
(BCG)
- In humans is it more effective than chemotherapy for bladder cancer?
- helpful for bladder cancer in dog? why?
- speed regression of TVT (?
A
- yes
- no - has more time to develop
- yes
9
Q
Just watch it/read it
A