(19) Antibacterial Immunity Flashcards
1
Q
- Are there a few bacteria cells where NK can come into play?
(unrelated) 2. What FE2 binding protein do bacteria make to compete with the host proteins?
A
- yes
- siderophores
2
Q
What are some imporant differences between eukaryotic and prokaryotic cells?
A
- ribosomes
- few sterols and cholesterols in prokaryotes
- bacteria replicate very quickly
- most bacteria small enough to be phagocytosed
3
Q
- Is there any correlation between shape/size/gram stain and pathogenesis?
- are there any gram-negative cocci of veterinary importance?
A
- no
- no
4
Q
- which type has thicker peptidoglycan?
- what layer of gram - has the LPS?
A
- gram +
- outer bilayer (the pro-inflammatory compoenent of gram -)
5
Q
- Peptidoglycan is a polysaccharide backbone composed of alternating residues of what and what?
- cross-linked via what?
- Teichoic acids are found in what? are what? can these be antigenic?
A
- N-acetylglucosamine and N-acetylmuramic acid
- peptide bridges
- gram +; repeating cross-linked simple sugars; yes
6
Q
- LPS (lipolysaccraride) found in what?
- aka what?
- highly what?
- what part of molecule is highly active?
A
- gram -
- endotoxin
- inflammatory
- lipid A
7
Q
- What are the 3 basic processes or components which prevent colonization by pathogenic bacteria?
A
- surface barriers, innate immunity, and adaptive immunity
8
Q
just read this
A
9
Q
- why no lyme disease in southwest
A
- powerful lizards kill bacteria in infected ticks
10
Q
- What are the most important cells in the innate defense against bacteria?
- mostly consist of what?
- Ingestion of the microorganisms cause what to fuse with what?
A
- phagocytes
- macrophages and neutrophils
- lyosomes with phagosome
11
Q
read pages 9 and 10 in this lecture (I think he just skipped them though)
A
12
Q
- the binding and phagocytosis of bacteria is greatly enchanced by what?
- The macrophages and neutophils have what that recognize opsonins?
- The receptors also signal the peptides to do what?
- What are the major opsonins (3 of them)?
A
- opsonization
- receptors
- activated the respiratory burst
- antibodies, complement C3b, lectin binding proteins (MBL, acute phase proteins)
13
Q
- Do phagocytes bear receptors that many bacterial structures, particularly CD14, CR3, (CD18/CD11c), Fc, and TLR that are specific for LPS?
- Are macrophages activated following encounter with bacteria?
A
- yes
- yes
14
Q
- Anti-microbial activites of phagolysomes are catergorized as what and what?
A
- oxidative and non-oxidative
15
Q
What are ROP made from?
A
NADPH oxidase