(01) Introduction Flashcards
What factors affect an immune response?
- age, nutritional status, host genetics, drugs, confounders/co-infections, stress, smoking
What type of immunology is self from non-self? Self from altered self? Damaged self?
- infectious agents (viruses, bacteria, fungi, parasites)
- neoplasia
- injury
Is innate immunity specific? Adaptive?
- not specific
- specific
What are the humoral components of Innate immunity?
- complement
- cytokines/chemokines
- antimicrobial peptides
What are the cellular components of innate immunity?
- monocytes (macrophages, dendritic cells)
- natural killer cells
- granulocytes (mast cells, eosinophils, basophils, neutrophils)
What are the humoral components of the adaptive immunity?
- antibodies
What are cellular components of the adaptive immunity?
- B cells
- T cells (helper t cells, cytotoxic cells, regulatory T cells)
What does innate immunity recognize? How about adaptive?
- proteins or entire pathogen
- epitopes (AA sequences on pathogens)
What is immunity mediated by? Where an immunocytes derived?
- organs, cells, and molecules
- bone marrow during hematopoesis
Three synonyms for innate and acquired?
- natural, existing, non-clonal
- acquired, induced, clonal
What are the three components of the immune system?
- Soluble components, Cellular components, tissues
What are the soluble components of the immune system released by? What do they do? What can they have direct action on?
- immune cells, fibroblasts, epithelial cells, hepatocytes, other cells
- Affect differentiation and activities of immune cells
- invading pathogens or tumors
What types of responses are carried out by the cellular components of the immune system?
- innate response and adaptive response
What types of organs are there in the tissues of the immune system?
- primary and secondary organs
Where do the cells of the immune system originate? Where do they migrate through? Where do they then mature and function?
- bone marrow
- blood and lymphatic system
- peripheral tissues