2.1 — nucleic acids: DNA and RNA Flashcards
covers: the structure of nucleotides; the reactions that synthesise and breakdown nucleic acids; the role and structures of DNA and RNA; the similarities and differences between DNA and RNA
what are nucleotides?
the building blocks of nucleic acids such as DNA and RNA
what dimers and polymers do nucleotides form?
dinucleotides and polynucleotides
what is a nucleic acid the functional molecule made up of?
one or more polynucleotide chains
what components make up a nucleotide?
- a pentose sugar — contains 5 carbon atoms
- a nitrogenous base — contains carbon and nitrogen
- a phosphate group — contains a phosphate group
how are polynucleotides made?
nucleotides are joined together via condensation reactions.
what type of bonds join the nucleotides in polynucleotides?
(covalent) phosphodiester bonds
how is a phosphodiester bonds formed?
when the phosphate group of one nucleotide forms a covalent bond with the sugar of another
what is a sugar phosphate backbone?
a chain of phosphates and sugars (joined by phosphodiester bonds)
how can a phosphodiester bond be broken?
hydrolysis reactions
what is released when phosphodiester bonds undergo hydrolysis reactions?
the nucleotide and monomers
what does DNA stand for?
deoxyribonucleic acids
what does DNA contain the information for?
the instructions needed to make proteins
what components make up a DNA nucleotide?
- deoxyribose sugar — a pentose/ 5 carbon sugar
- A, T, G, or C —nitrogen containing organic base
- a phosphate group
who was credited in working the structure of DNA?
James Watson and Francis Crick
what is the structure of DNA made up of?
two polynucleotide strands wound around each other to form a double helix
what are the features that allow DNA to pass genetic information from one generation to another?
- sugar phosphate backbone — protects coding bases on the inside of the helix
- double stranded — allows strands to act as templates in DNA replication
- large molecule — stores lots of information
- double helix — makes it compact
- complimentary base pairing — allows accurate DNA replication
- weak hydrogen bonds — allows strands to serve rate in DNA replication
how does having a sugar phosphate backbone allow DNA to pass genetic information?
protects coding bases on the inside of the helix
how does being double stranded allow DNA to pass genetic information?
this allows strands to act as templates in DNA replication
how does being a large molecule allow DNA to pass genetic information?
it stores a lot of information
how does being a double helix allow DNA to pass genetic information?
makes the molecule compact
how does having complimentary base pairing allow DNA to pass genetic information?
allows accurate DNA replication
how does having a weak hydrogen bonds allow DNA to pass genetic information?
they allow strands to separate in DNA replication
what are the four nitrogenous bases found in DNA?
adenine (A), guanine (G), thymine (T) and cytosine (C)
what groups can the nitrogenous bases in DNA be grouped into?
purines and pyrimidines
what nitrogenous bases in DNA are purines?
adenine and guanine
what nitrogenous bases in DNA are pyrimidines?
thymine and cytosine
what is a purine?
larger nitrogenous bases that contain two carbon ring structures (A and G)
what is a pyrimidine?
smaller nitrogenous bases that contain one carbon ring structures (T and C)
how are the complimentary base pairings in DNA held together?
by hydrogen bonds (between A+T and C+G)
what type and how many bonds form between adenine and its complimentary base?
two hydrogen bonds between adenine and thymine
what type and how many bonds form between cytosine and its complimentary base?
three hydrogen bonds between cytosine and guanine
what allows a constant distance between the two sugar phosphate backbones of the DNA double helix?
the (smaller) pyrimidine bases always bond to the (larger) purine bases.
what does RNA stand for
ribonucleic acid
what is RNA?
a nucleic acid that uses information from DNA to synthesise proteins
what is RNA made from?
- ribose — a pentose sugar
- A, U, G, or C — nitrogen containing organic base
- a phosphate group
unlike DNA, RNA nucleotides contain the sugar ______ rather than __________. they also contain the base ______ in place of _______.
fill in the missing terms:
- ribose
- deoxyribose
- uracil
- thymine
what is RNA?
RNA is a single stranded molecule made up of just one polynucleotide strand, which are much shorter than DNA strands.
what pentose sugar does DNA contain?
deoxyribose
what pentose sugar does RNA contain?
ribose
what bases does DNA contain?
A, T, G, C
what bases does RNA contain?
A, U, G, C
what is the relative size of DNA?
long
what is the relative size of RNA?
relatively short
what is the number of strands in DNA?
2
what is the number of strands in RNA?
1