2017 Pharmacology - Pharmacodynamics Flashcards

1
Q

How do you define drug Efficacy?

A

it is the strength of a single drug-receptor interaction that evokes a response

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2
Q

What are Agonists and what do they cause?

A

drugs that bind to receptors and produce some effect similar to the response produced by endogenous agents, they possess intrinsic activity

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3
Q

What are Antagonists and what do they cause?

A

drugs that bind to receptors but DO NOT produce an effect, they possess no intrinsic activity.

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4
Q

What 2 things affect drug-receptor interactions?

A

Binding forces Structure Activity Relationships

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5
Q

What are the differences between Graded vs. Quantal Dose-Response Curves?

A

Quantal - based on all or none response, provides estimate of percent of subjects who will respond to any given dose

Graded - based on data from single subjects, provides info about potency and efficacy

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6
Q

What does a quantal dose response curve look like?

A
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7
Q

What does a graded dose response curve look like?

A

X is more potent, lower [x] needed to get EC50

X has a higher efficacy than Y

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8
Q

What are 4 key features of Competative Antagonists?

A

Reversible binding to receptor

Blockade can be overcome by increasing [agonist]

maximal response of agonist is not decreased

agonist dose-response curve in presence of competative antagonist is displaced to the right and parallel

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9
Q

What are features of Irreversible Competative Antagonists?

A

Typically covalently bound

Maximal response is deminished

Cannot overcome antagonist w/ increased agonist concentration

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10
Q

What are features of Partial Antagonists?

A

decrease the maximal response

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11
Q

Features of Non-competitive Antagonism?

A

antagonist does not bind to active site

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12
Q

What is an Inverse Agonist?

A

Binds to receptor site like an Agonist but has the opposite effect of the normal Agonist

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13
Q

Understand levels of response for Full agonists, partial agonists, inverse agonists and antagonists.

A
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14
Q

What are two types of changes in receptor sensitivity that can occur?

A

Desensitization - deminished response, altered binding of drug to receptor, lack or receptors, decreased coupling of drug-receptor complex & signaling

Supersentitization - increased response, can be drug induced or pathophysiological.

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15
Q
A
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