2017 Microbiology - RNA Viruses and Diseases

Question 1

What family is Rhinovirus from, general disease characteristics, Dx method?

Answer 1

Picornaviruses
Linear, +ssRNA, icosahedral, naked

Infection via nose, outh, eyes.
Coryza (runny nose), via brandykinin and histamine release.

Disease: Common cold
Acute bronchitis in kids less than 2yo.

Question 2

What are the 2 most common causes for common colds?

Answer 2

Rhinovirus

Coronavirus

Question 3

What family is Poliovirus from, general disease characteristics, Dx method?

Answer 3

Picornaviruses - Enteriovirus

Aseptic meningitis, encephalitis
varying degrees of flacid paralysis

Dx by culture, serology, immuno-based methods

Question 4

What family is Coxsackie A from, general disease characteristics, Dx method?

Answer 4

Picornaviruses - Enteriovirus

Diseases:
Herpangia
Aseptic meningitis
Encephalitis
Common cold
Hand-foot-mouth disease
Acute hemorrhagic conjunctivitis
Acute pharyngitis or tonsillitis
GI sx. in infants
Myocarditis/Pericarditis

Dx.
CSF shows lymphocytic pleocytosis for aspetic meningitis
Echocardiography for Myocarditis/Pericarditis

Question 5

What virus is commonly responsible for infant diarrhea?

Answer 5

Coxsackie A24 virus

Question 6

What virus is most commonly responsible for Myocarditis and Pericarditis?

Answer 6

Coxsackie B virus

Question 7

What virus is associated with fever, headache, myalgias, hepatitis w/ jaundice, GI hemorrhage and renal damage?

Answer 7

Yellow Fever Virus (Flaviviridae family)

Question 8

What virus is associated with flu-like symptoms, break bone fever, and in some cases hemorrhagic fever syndrome.

Answer 8

Dengue Fever (Flaviviridae family)

Question 9

This virus causes Chronic Hepatitis

Answer 9

Hepatitis C (Flaviviridae family)

Question 10

This disease causes progressive encephalitis, fever, HA, myalgias, fear of water, CNS sx. and microscopic exam shows viral inclusions and Nergi bodies?

Answer 10

Rabies virus (Rhabdoviridae family)

Question 11

This virus is transmitted via monkeys. Symptoms include: extensive tissue destruction including liver, spleen, lymph nodes, and lungs. Cell lysis can lead to hemorrhage and hypovolemic shock.

Answer 11

Marbury and Ebola Viruses (Filoviridae family)

Question 12

This virus is responsible for the common cold and SARS outbreaks. Transmission is via nasal droplets.
Virus typically has halo or corona of club shaped surface projections.

Answer 12

Coronavirus (Coronaviridae family)

Question 13

This virus is responsible for Summer Diarrhea and epidemic diarrhea.

The nucleoplasmid has a tubular shape that can be bend into an open torus or kidney shape.

Answer 13

Toravirus (Coronaviridae family)

Question 14

This is virus is responsible for Croup in children and infections of the upper and/or lower RT.

Answer 14

Parainfluenza virus (Paramyxoviridae virus)

Question 15

This disease is characterized by epidemic parotitis, chills, headache, malaise, sublingual swelling.

Answer 15

Mumps (Paramyxoviridae virus)

Question 16

This disease is characterize by cough, coryza, severe rash, Koplik Spots in the oral cavity,

Answer 16

Measles (Paramyxoviridae family)

Question 17

This virus is responsible for Bronchiolitis in children <2 yo., cold, acute otitis, croup.

Answer 17

Respiratory Syncitial virus (Paramyoxviridae family)

Question 18

This disease is responsible for the typical “flu”, pneumonia

Answer 18

Influenza (Orthomyxo-viridae family)

Question 19

This virus is responsible for Hand-foot-and-mouth disease, hepangina (oral vesicular lesions), acute hemorrhagic conjunctivitis and the common cold.

Answer 19

Coxsackie Virus A (Picornaviridae - enterovirus)

Question 20

This virus is responsible for Myocarditis and Pericarditis.

Answer 20

Coxsackie Virus B (Picornaviridae - enterovirus)

Question 21

This virus is responsible for sudden onset icterus, fecal-oral transmission, liver dysfunction.

Answer 21

Hepatitis A (Picornaviridae - enterovirus)

Question 22

This virus is responsible for summer-diarrhea, especially for children.

Answer 22

Norovirus (Calciviridae family)

Question 23

This virus is responsible for viral gastroenteritis as well as summer diarrhea, higher rate of infection in children than Norovirus.

Answer 23

Astrovirus (Calciviridae family)

Question 24

This virus is responsible for Acute Infantile Diarrhea - winter diarrhea.

Answer 24

Rotavirus (Reoviridae family)