19. Her 2 Flashcards
1
Q
what is Her2?
A
epidermal GF
2
Q
what ch is Her on?
A
17
3
Q
what is \her2 involved in the signalling of? (4)
A
- embryogenesis
- cell growth
- cell differentiation
- apoptosis
4
Q
in what % of BC is Her 2 overexpressed?
A
10-20%
5
Q
treatment for prescenceof Her2?
A
herceptin = trastuzumab
6
Q
what 2 things is Her 2 grading dependent on?
A
- intensity
2. completeness of staining cell membrane
7
Q
in what grading is herceptin treatment given?
A
3+
8
Q
what occurs if the grading is 2+?
A
FISH
9
Q
what is a lumpectomy/open biopsy?
A
remove all/part of lump
10
Q
what is a mastectomy?
A
removal of breast tissue + axillary lymph nodes
11
Q
what is a sentinel lymph node biopsy?
A
removal of sentinel lymph nodes
12
Q
when deciding treatment - which is the only cancer we should look at?
A
invasive
