16. female hormonal control of reproduction and infertility Flashcards

1
Q

how long is the ovulatory phase?

A

36hrs

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2
Q

4 phases of menstrual cycle

A
  1. menstruation
  2. follicular
  3. obuvalory
  4. luteal
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3
Q

during ovulation which 2 hormones increase and which decrease?

A

increase - Oestrogen and progesterone

decrease - LH and FSH

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4
Q

2 functions of oestrogen

A
  1. endometrial proliferation

2. maturation of vaginal epithelium

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5
Q

describe feedback of oestrogen

A
follicular = negative feedback 
ovulatory = positibe feedback
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6
Q

describe pathway of how oestrogen is produced

A
  1. hypo - GnRH
  2. Ant pit - LH and FSH
  3. ovary follicle - oestradiol
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7
Q

what produces inhibin?

A

follicle

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8
Q

what produces progesterone?

A

corpus luteum

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9
Q

function of progesterone

A
  1. increase in body T

2. thick cervical mucus secretion

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10
Q

what occurs during follicular phase

A
  1. FSH causes growth of follicle
  2. follicle secretes oestrodiol
  3. inhibin + oestrodiol cause negative feedback on FSH
  4. FSH decreases
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11
Q

what occurs during the ovulatory phase

A
  1. oestrdiol causes positive feedback
  2. LH surge
  3. oocyte maturation
  4. release of ovum
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12
Q

what occurs during the luteal phase?

A
  1. follicles become corpus luteum
  2. CL secrete oestraoil and progesterone
  3. progesterone maintains endometrium
  4. CL involutes by macrophage
  5. oestradiol + prog decline
  6. menstruation
  7. loss of negative feedback
  8. FSH rises
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13
Q

what does the ovum secrete (fertilised)?

A

human chorionic gonadotrophin (hCG)

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14
Q

role of hCG?

A

maintains Corpus luteum

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15
Q

what is precocious puberty

A

puberty before age of 8

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16
Q

2 causes of precocious puberty

A
  1. brain tumour - increase in FSH/LH

2. ovarian tumour - increase in oestrogen

17
Q

5 causes of delayed puberty

A
  1. consititutinal delay
  2. hypothalamic disease
  3. ovarian diease
  4. pituitary disease
  5. chronic illness
18
Q

what is hypothalamic disease?

A

LHRH deficinecy

19
Q

5 causes of hypothalamic disease

A
  1. eating disorder
  2. stress
  3. chronic illness
  4. cranial irradiation
  5. brain tumour
20
Q

what syndrome can hypothalamic disease cause?

A

Kallman’s - anosmia

21
Q

what disease can haemochromatosis (iron overload) lead to?

A

hypopituitarism

22
Q

what is polycystic ovary syndrome?

A

High LH

23
Q

what is hyperpro-lactinaemia?

A

high levels of prolactin inhibit ovulation

24
Q

how to treat hyperpro-lactinaemia?

A

DA agonists

25
Q

what is hypothalamic amenorrhoae?

A

menstruation stops for a couple of months

26
Q

treatment of hypothalamic amenorrhoae?

A

LHRH administration

27
Q

what is endometriosis?

A

abnormal proliferation of endometrium outside the uterus

28
Q

treatment of endometriosis?

A

LHRH - reducing progesterone to break down tissue

29
Q

what does COP mimic?

A

luteal phase

30
Q

what does COP reduce?

A

LH and FSH

31
Q

how does POP work?

A

makes cervical mucus impermeable to sperm