17. Breast cancer Flashcards
1
Q
which muscle separates the breasts from the ribs
A
pec major
2
Q
which breast cancer origin is 85%?
A
ductal
3
Q
how many BC pt are oestrogen receptor positive?
A
60-70%
4
Q
which patients are candidates for endocrine therapy?
A
oestrogen receptor +ve
5
Q
3 main types of oestrogen?
A
oestradiol
oestrone
oestriol
6
Q
when is oestradiol secreted?
A
after puberty
7
Q
when is oestrone secretted?
A
after menopause
8
Q
when is oestiol secreted?
A
pregnancy
9
Q
what can supraphysiological oestrogen levels cause?
A
kill ER +ve cells
10
Q
what cancer can be caused by high oestrogen levels?
A
uterine
11
Q
3 postmenopausal changes which occur due to a lack of oestrogen?
A
- dec bone mass
- insulin reisstance
- high CVD risk
12
Q
4 advantages of oestrogen replacement therapy as a treatment for menopause?
A
- increases HDL
- lowers LDL
- strengthens bone
- reduces menopausal sxs
13
Q
classical receptor
A
ER-alpha
14
Q
new receptor
A
ER-beta
15
Q
where is the classical receptor found
A
Ch6
