17. Breast cancer Flashcards
(24 cards)
which muscle separates the breasts from the ribs
pec major
which breast cancer origin is 85%?
ductal
how many BC pt are oestrogen receptor positive?
60-70%
which patients are candidates for endocrine therapy?
oestrogen receptor +ve
3 main types of oestrogen?
oestradiol
oestrone
oestriol
when is oestradiol secreted?
after puberty
when is oestrone secretted?
after menopause
when is oestiol secreted?
pregnancy
what can supraphysiological oestrogen levels cause?
kill ER +ve cells
what cancer can be caused by high oestrogen levels?
uterine
3 postmenopausal changes which occur due to a lack of oestrogen?
- dec bone mass
- insulin reisstance
- high CVD risk
4 advantages of oestrogen replacement therapy as a treatment for menopause?
- increases HDL
- lowers LDL
- strengthens bone
- reduces menopausal sxs
classical receptor
ER-alpha
new receptor
ER-beta
where is the classical receptor found
Ch6
where is the new receptor found
Ch14
2 examples of SERMS drugs
tamoxifen and raloxifine
who is tamoxifen used for?
ER+ve women
effect of tamoxifen on breast tissue
- binds to receptor
- causes conformational change in protien
- reduces cancer cell growth and differentiation
effect of tamoxifen on endometrium
- binds to receptor
2. activates oestrogen regulated genes
how do aromatase inhibitors work?
inhibit conversion of DHEA to oestrogen
action of type 1 aromatase inhibitor
forms permanent and deactivating bond with enzyme
action of type 2 aromatase inhibitor
reversible competition with the enzyme
what do phytooestrogens attach to?
ERb
