18: Fibrous CT Flashcards
Most abundant tissue type
CT
ECM in bone
Mineralized
Type I collagen function
Resists tension
Most abundant protein in the body
Collagen
Fibrils in collagen
Are secreted as pro-collagen, aligned and cross linked
Type I collagen composition
2 collagen type a1 chains + 1 collagen type a2 chain
Syndecans
Receptors that bind GF
Syndecans composition
Contain multiple Heparan sulfate proteoglycans
CD44: what it binds
Hyaluronan
Four types of membranes
Mucous, serous, cutaneous, synovial
What is a membrane?
Epithelium + CT
Cutaneous membrane
Skin
Mutation in Marfan’s syndrome
Fibrillin-1 gene
Fiber type affected in Marfan’s
Elastin
Genetics of Marfan’s syndrome
Autosomal dominant
Three principle targets in Marfan’s syndrome
Ocular, skeletal, CV
Phenotype of someone with Marfan’s syndrome
Tall with long arms and legs, often life-threatening CV anomalies
