(15) Spirochetes

Question 1

(Brachy Hyodysenteriae - most important)

1. Disease
2. Host
3. Transmission
4. Clinical Signs
5. Path
6. Diagnosis
7. Treatment
8. Immunity
9. Notes?

Answer 1

1. swine dysentery (bloody scours)
2. swine
3. fecal/oral (anaerobe but lives in feces)
4. GI upset - 10-30% death from dehyrdation

those that live = poor-doers

5. colonize colonic mucosa - virulence factor chemotactic for intenstinal mucins - release endotoxin and hemolysin
6. Cx, organism in feces, serology, PCR
7. penicllin (increasing resitance to lincomycin and tylosin)
8. no vx
9. doens’t dvelop disease alone

Question 2

(Brachy Pilosicoli)

1. Disease
2. Host
3. What is it basically?
4. get what?
5. works together with what?

Answer 2

1. Porcine Colonic Spirochetosis
2. swine
3. less severe swine dysenteray
4. Gi upset/diarrhea (no death)
5. helicobacter

Question 3

(Leptospira Interrogans)

2. Host
3. Transmission
4. Clinical Signs
5. Path
6. Diagnosis
7. Treatment
8. Immunity
9. serovars?

based on?

Answer 3

2. horses, dogs, humans, cattle, sheep
3. transplacental, urine
4. first 7 days - leptospirema/low grade fever

next 2-3 months - leptospuria

5. enter MM of urogenital/nasal –> colonize eyes, lungs, kidney, liver, repro (low immune places)

primary repro in liver (chemotactic for hemoglobin)

chronic once established in kidney

6. dark field, fluorscent Ab, serology, kidney enzymes deactivated
7. penicillin (doesn’t clear carrier state)
8. a yr vx
9. diff serovars have diff severity/sp specificity

surface antigens

Question 4

(Borrelia Anserina)

1. Disease
2. Host
3. Transmission
4. Clinical Signs
5. most common where?

Answer 4

1. Fowl spirochetosis
2. chickens, turkeys, geese, etc (young)
3. fowl ticks
4. genx, swollen spleen
5. tropics

Question 5

(Borrelia Burgdorferi)

1. Disease
2. Host
3. Transmission
4. Clinical Signs
5. Path
6. Diagnosis
7. Treatment
8. Immunity
9. What species causes in humans?

is there direct transmission btwn dogs/humans?

Answer 5

1. Lyme Disease
2. rodent, deer,

accidental = human, horse, dog

3. rodent –> tick –> deer
4. bullseye, not all dogs get illness

genx

5. from immune response (flagellin makes Ab that cross reacts with neuroaxonal proteins)

Borrelia can switch surface antigens to avoid Ab

6. Cx, tick exposure, sero (takes 3wks to see high titer)
7. doxycycline and amoxicillin (long term)

NSAIDS for pain

8. vx (causes arthritis)
9. Sensu Latu (4 types)

no