(03) Mycoplasma

Question 1

(Mycoplasma)

(Class: Mollicutes)

1. similar to rickettsiales how?
2. gram?
3. involved in what kind of disease?
4. what are the smallest, free living unicelluar organism capapble of reproduction in the absence of host cells?
5. oxygen?
6. specifically adapted to hosts
7. invasive to cells?
8. transmission is almost always what?
9. avoid immune rec by doing what?
10. activate complement
11. several spceis make what?

Answer 1

1. weak gram reaction

also have very little(actaully no) PTG (sens to environment)

2. -
3. generalized, chronic, low grade

exacerbate/predispose to other things

4. mycoplasma (rickettsiales have to use host cell for example)
5. aero and anaero
6. no - stick to the surface
7. direct contact
8. change surface antigens
9. H2O2

Question 2

(Mycoplasmas)

1. associated with their hosts - often as commensals
2. how easy to culture?

why?

Answer 2

2. hard

small genome - need a lot of materials

Question 3

(Mycoplasmas)

1. associated with host cell surfaces - non-invasice
2. often have what role in disease?

3-5 have what three virulence mechanisms?

Answer 3

2. uncertain
3. superoxide and H2O2
4. surface protein that binds epi cells
5. toxins

Question 4

(Mycoplasmas)

(Diagnosis/treatment/immunity)

1. what most helpful?
2. difficult to culture - often mixed - what helps?
3. is serology useful?
4. treatment with what?
5. vx?
6. immunity after exposure?

Answer 4

1. clinical signs
2. penicillin - kills stuff with PTG
3. yes
4. tetracycline and erythromicin
5. yes - but not very effective?
6. no - get relapses