12.8 Cognitive Disorders Flashcards
An acute confusional state
marked by prominent alterations in perception and consciousness
delirium
delirium is a _________ course of consciousness/level of arousal
fluctuating
people with delusion in terms of orientation loss lose _______ then ______ then ________
time
place
person
deterioration in function in multiple cognitive/intellectual areas in a person who has previously been “normal”
dementia
alzheimers is a decline of memory, but what else must it have?
at least one other domain of cognitive function
aphasia
apraxia
agnosia
executive dysfunction
agnosia
loss of insight or understanding of what is going on
lack of sensory understanding
atrophy starts in the ________ and __________, and as the illness worsens clinically
entorhinal cortex
hippocampus
eventually in Alzheimer’s, the atrophy spreads to all areas of the brain but the ________________
occipital lobe
what are the two types of drugs we use for Alzheimers?
Acetylcholinesterase inhibitors
NMDA antagonists
donepezil
use
mechanism
Alzheimer’s
acetylcholinesterase inhibitor that crosses the BBB
memantine
use
mechanism
Alzheimer’s
NMDA channel antagonist at “open state”
vascular dementia is an accumulation of __________
strokes
where are Lewy bodies in Lewy body dementia?
brain stem and also are widespread throughout the cerebral cortex
where are Lewy bodies in Lewy body dementia?
substantia nigra dopamanergic neurons
In Lewy body dementia, patients have problems with _________ first and then eventually ________
cognition
motor
