11.28 Synaptic Plasticity

Question 1

what are the two major class of molecules that are responsible for long term changes? (protein synthesis) in a model of LTP, for example

Answer 1

1) BDNF/trkB

2) cFos, Fos/Jun, AP-1 transcription factor complex

Question 2

what does Ca++ do for LTP?

Answer 2

changes protein transcription levels, long-term changes in the cell

Question 3

without the c-Fos gene, there are deficits in ______________________

Answer 3

learning and memory

Question 4

Fos and Jun make the ______________

Answer 4

AP-1 Transcription factor Complex

Question 5

sensory experience causes synaptic activity that can induce _____ transcription and ____ protein

Answer 5

c-Fos, c-Fos

Question 6

what ions does the NMDA channel let in when it opens?

Answer 6

Na+ and Ca++

Question 7

LTP can result in ________ of a synaptic connection and even the ________________________

Answer 7

strengthening

formation of a new synapse

Question 8

BDNF binds to _________, which then does what?

Answer 8

trkB

the trkB/BDNF complex travels back to alter transcription/translation

Question 9

_____ and _____ together comprise the AP-1 Transcription factor complex

Answer 9

Fos

Jun

Question 10

______ channels have a magnesium block that is only kicked out when there is _________

Answer 10

NMDA

depolarization

Question 11

the entry of _____ into the post-synaptic cell sets in motion the events that produce LTP

Answer 11

Ca++

Question 12

_____ occurs when there is a loss of synaptic excitability and decrease in synthesis of certain proteins

Answer 12

LTD