11.5 Schizophrenia Flashcards

1
Q

schizophrenia gets ______ over time

A

worse

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2
Q

the ________ symptoms of schizophrenia may have a greater functional impact and are more difficult to treat

A

negative

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3
Q

what are the positive symptoms of schizophrenia?

A

hallucinations or delusions

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4
Q

visual hallucinations in schizophrenia appear ______ sized and persist with the eyes _______________.

A

regular

open or closed

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5
Q

firmly held beliefs, despite evidence on the contrary, that others do not find credible or that are not shared by others

A

delusions

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6
Q

what are the three types of schizophrenia?

A

paranoid type
disorganized type
catatonic type

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7
Q

the __________ type of schizophrenia usually has less negative symptoms and thus a better prognosis over time

A

paranoid

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8
Q

_________ type of schizophrenia has disturbance in motor function

A

catatonic type

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9
Q

the type of schizophrenia that has a regression to primitive, disinhibited, unorganized behaviors

active but in an aimless manner

A

disorganized type

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10
Q

what is waxy flexibility? where do you see this?

A

when you put someone into a position, they stay there

catatonic type schizophrenia

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11
Q

what is the most common age for onset of schizophrenia?

A

in adolescence, before the age of 25

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12
Q

what are easier to treat in schizophrenia? the positive or negative symptoms? why?

A

the positive symptoms

we do not have good drugs to target the negative symptoms

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13
Q

in macroscopic examination of patients with schizophrenia, there are enlarged __________

A

ventricles

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14
Q

in schizophrenia, there are volume reductions and decreased blood flow to _______________ cortex

A

prefrontal/orbitofrontal

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15
Q

In schizophrenia, there is reduced volume in what part of the thalamus?

A

DM nucleus

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16
Q

in schizophrenia patients, there is progressive loss of gray matter in front-_________ areas

A

temporal

17
Q

an increase in what NT is characterized in schizophrenia?

A

domapine

18
Q

in schizophrenic patients, there seems to be an increase in _______ interactions at _____ receptors in the frontal cortex and basal ganglia

A

dopamine

D2

19
Q

what are the two major types of drugs for antipsychotics?

A

typical and atypical

20
Q

atypical antipsychotics are better at treating what types of schizophrenia symptoms?

A

positive AND negative

21
Q

typical antipsychotics are better at treating what types of schizophrenia symptoms?

A

positive

22
Q

which one has more extrapyramidal side effects? atypical/typical antipsychotics

A

atypical

23
Q

Fluphenazine

what is it used for?
mechanism of action
side effects

A

psychosis (eg. Schizophrenia)

Antagonist at dopamine D2, D4, D1, adrenergic α1, serotonin 5-HT2, histamine H1, muscarinic receptors

extrapyramidal effects, sedation, lactation, hypotension

24
Q

Haloperidol

what is it used for?
mechanism of action
side effects

A

psychosis (eg. Schizophrenia)

Antagonist at dopamine D2, D4, D1, adrenergic α1, serotonin 5-HT2, histamine H1

extrapyramidal effects, sedation, lactation, hypotension

25
Q

what are 4 features of extrapyramidal reactions?

A

pseudoparkinsonism (bradykinesia, pill tremor, etc)

akathisia (restlessness)

acute dystonia (stiff, rigid, spasms)

tardative dyskinesia (facial tics, grimacing, tongue movements)

26
Q

olanzepine

what is it used for?
mechanism of action
side effects

A

antipsychotic (schizophrenia) - atypical type

antagonist at 5HT2, D2/D4, muscarinic, histamine, adrenergic

sedation, hypotension, some extrapyramidal

27
Q

aripiprazole

what is it used for?
mechanism of action
side effects

A

antipsychotic (schizophrenia) - atypical type

partial agonist at D2 receptor and 5HT1a

sedation, hypotension

28
Q

clozapine

what is it used for?
mechanism of action
side effects

A

antipsychotic (schizophrenia) - atypical type

antagonist at 5HT2, D4/D2/D1, histamine, muscarinic, adrenergic

sedation, hypotension, some extrapyramidal

29
Q

quetiapine

what is it used for?
mechanism
side effects

A

antipsychotic (schizophrenia) - atypical type

antagonist at 5HT2, 5HT1a, D1/D2, muscarinic, histamine, adrenergic

sedation, hypotension, some extrapyramidal