1.27 Detoxification activity of the liver Flashcards
1
Q
Give the products of detoxification methods
A
- Urea
- Uric acid
- Allantoin
- Glutamine
2
Q
Urea
A
Produced by arginase
Ø in birds
3
Q
Uric acid is excreted by
A
- Humans
- Primates
- Birds
- Dalmation dogs
4
Q
Allantoine
A
Produced by uricase
- Dog
- Cat
- Horse
- Ru
- Sus
5
Q
Glutamine degradation
A
Glutamine → NH3 → NH4+
Glutaminase
6
Q
Give the detoxification methods of the liver
A
- Hydroxylation
- Ethanol oxidation
- Reduction of insulin
- Conjugation with:
- Glucuronic acid
- Sulphuric acid
- Amino acids
7
Q
Hydroxylation
A
-
Cytochrome P450:
- Addition of OH groups → More water soluble
- Steroid hydroxylase:
- Mixed function oxygenase
8
Q
Draw detoxification by hydroxylation
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/279/622/719/a_image_thumb.png?1559573191)
9
Q
Draw ethanol oxidation
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/279/622/767/a_image_thumb.png?1559573226)
10
Q
Draw reduction of insulin
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/279/622/807/a_image_thumb.png?1559573377)
11
Q
Describe hydrolysis by cardiac glycosides
A
- Digitalis purpea plant
- Hydrolysis between sugar + steroid
12
Q
Draw conjugation with: glucuronic acid
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/279/623/079/a_image_thumb.png?1559573484)
13
Q
Draw conjugation with: Sulphuric acid
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/279/623/122/a_image_thumb.png?1559573545)
14
Q
Draw conjugation with: Amino acid
A
![](https://s3.amazonaws.com/brainscape-prod/system/cm/279/623/260/a_image_thumb.png?1559573582)