1.19 Degradation of fatty acids: β-oxidation Flashcards
How are fatty acids transported into the mitochondrial matrix?
- Short FFA pass through the outer + inner membrane
- Long FFA pass through outer membrane, but require a carrier to pass the inner membrane
Draw the transport of long-chain FFAs into the mitochondria
CAT = Carnitine acyl transferase
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Draw β-oxidation of even FFAs with even carbon atoms
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Give the steps of β-oxidation of even chain FFAs
- FA-SCoA
- Trans-2-enoyl-FA-SCoA
- β-OH-FA-SCoA
- β-keto-FA-SCoA
- Fatty acyl-SCoA
Draw the pathway of odd carbon β-oxidation
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Give the regulation of β-oxidation
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Give the location of β-oxidation
Liver, muscle - Mitochondrial matrix
Give the energy balance of β-oxidation
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β-oxidation of unsaturated fatty acids requires…
An extra step
Cis-β,γFA → Trans-β,γFA
Draw the reaction of Cis-β,γFA → Trans-β,γFA
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What is the difference in the end product between odd and even carbon β-oxidation?
Even: AcCoA (Fatty acyl-SCoA)
Odd: Propionyl-CoA
The end product of odd-carbon β-oxidation is used in…
GNG
Give the energy balance of odd carbon β-oxidation
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