1.19 Degradation of fatty acids: β-oxidation

Question 1

How are fatty acids transported into the mitochondrial matrix?

Answer 1

• Short FFA pass through the outer + inner membrane
• Long FFA pass through outer membrane, but require a carrier to pass the inner membrane

Question 2

Draw the transport of long-chain FFAs into the mitochondria

Answer 2

CAT = Carnitine acyl transferase

Question 3

Draw β-oxidation of even FFAs with even carbon atoms

Answer 3

Question 4

Give the steps of β-oxidation of even chain FFAs

Answer 4

1. FA-SCoA
2. Trans-2-enoyl-FA-SCoA
3. β-OH-FA-SCoA
4. β-keto-FA-SCoA
5. Fatty acyl-SCoA

Question 5

Draw the pathway of odd carbon β-oxidation

Answer 5

Question 6

Give the regulation of β-oxidation

Answer 6

Question 7

Give the location of β-oxidation

Answer 7

Liver, muscle - Mitochondrial matrix

Question 8

Give the energy balance of β-oxidation

Answer 8

Question 9

β-oxidation of unsaturated fatty acids requires…

Answer 9

An extra step

Cis-β,γFA → Trans-β,γFA

Question 10

Draw the reaction of Cis-β,γFA → Trans-β,γFA

Answer 10

Question 11

What is the difference in the end product between odd and even carbon β-oxidation?

Answer 11

Even: AcCoA (Fatty acyl-SCoA)

Odd: Propionyl-CoA

Question 12

The end product of odd-carbon β-oxidation is used in…

Answer 12

GNG

Question 13

Give the energy balance of odd carbon β-oxidation

Answer 13