1.1 Oxidative degradation of fuel molecules Flashcards
Draw AMP
Give the two methods of producing ATP from different substrates
- Oxidative phosphorylation
- Substrate-level phosphorylation
Substrate-level phosphorylation
- Direct phosphorylation of ADP from phosphorylated intermediates
- Seen during glycolysis/GTP-forming step in citric acid cycle
Give a ‘high energy’ bond
Phosphoanhydride bond
What gives ‘high energy’ bonds their energy?
- A large negative free energy change (ΔG) of hydrolysis
- High group transfer potential
AMP function
- Energy sensor
- Regulator of metabolism
- Stimulates metabolic pathways → ATP
Use of phosphocreatine/ creatine phosphate
- Used in nerve and muscle cells
- Storage of ~P bonds
What reaction does creatine kinase catalyse?
Phosphocreatine + ADP ↔ ATP + creatine
Where does creatine synthesis occur?
- Kidney (1st reaction)
- Liver (2nd reaction)
What regulates creatine synthesis?
Arg-Gly transamidinase
Name the high energy bond found between a carboxylic acid and a thiol group of coenzyme A
Thioester bond
Acetyl ~ CoA
The spontaneity of thioester cleavage is essential to the role of coenzyme A as an…
Acyl group carrier
Give the reaction for thioester bond formation
Free energy change of: Phosphocreatine
-43.1 kJ/mol
Free energy change of: Thioester bonds
-31.48 kJ/mol
Draw oxidative degradation of fuel molecules
Rxns can be anabolic, catabolic, or amphibolic
Give the 1st and second reactions for Creatine synthesis
Draw the dehydration of creatine
- Non-reversible*
- Occurs in the muscle*
