12. Adrenals, Ureter and Bladder Flashcards
paired endocrine glands situated over the medial aspect of the upper poles of each kidney.
adrenal glands
shape of right adrenal gland
pyramidal in shape
shape of left adrenal gland
semi-lunar
encloses the adrenal glands and the kidneys. This fascia attaches the glands to the crura of the diaphragm.
They are separated from the kidneys by the perirenal fat.
renal fascia /perinephric fascia
The adrenal glands consist of
capsule
cortex
medulla
Veins and lymphatics leave each adrenal gland via
hilum
arteries and nerves enter the glands at numerous sites.
adrenal cortex is derived from
embyronic mesoderm
adrenal medulla is derived from
ectodermal neural crest cells
this portion of adrenal gland is yellowish in color
cortex
cortex can be divided into 3 zones
superficial -> deep
- zona glomerulosa
- zona fasciculata
- zona reticularis
produces and secretes mineralocorticoids such as aldosterone.
Zona glomerulosa
produces and secretes corticosteroids such as cortisol. It also secretes a small amount of androgens.
Zona fasciculata
produces and secretes androgens such as dehydroepiandrosterone (DHES). It also secretes a small amount of corticosteroids.
Zona reticularis
dark brown in colour
portion of the adrenal gland
medulla
medulla contains this cells
chromaffin cells
secrete catecholamines (such as adrenaline) into the bloodstream in response to stress
also secrete enkephalins which function in pain control.
chromaffin cells
adrenal glands have a rich blood supply via three main arteries
Superior adrenal artery – arises from the inferior phrenic artery
Middle adrenal artery – arises from the abdominal aorta.
Inferior adrenal artery – arises from the renal arteries.
venous drainage of the adrenal glands
Right and left adrenal veins drain the glands.
The right adrenal vein drains into the inferior vena cava, whereas the left adrenal vein drains into the left renal vein.
innervation of the adrenal gland
coeliac plexus
greater splanchnic nerves.
Sympathetic innervation to the adrenal medulla - mainly from the T10 to L1 spinal cord segments.
lymphatic drainage of adrenal glands
lumbar lymph nodes by adrenal lymphatic vessels.
These vessels originate from two lymphatic plexuses – one deep to the capsule, and the other in the medulla.
a tumour of the adrenal medulla or preganglionic sympathetic neurones. It secretes adrenaline and noradrenaline uncontrollably, causing blood pressure to greatly increase.
Patients may present with palpitations, headaches and diaphoresis (profuse sweating).
pheochromocytoma
competitive, irreversible antagonist of adrenaline, can be used in treatment to reduce blood pressure by binding to adrenaline receptors, making less available for adrenaline to act upon.
phenoxybenzamine
adrenal gland
normal weight
4 grams
75% of the cortex is the
zone fasciculata
adrenocortical insufficiency characterized by : inc. pigmentation muscular weakness weight loss hypotension
Addison disease
cortical hyperplasia due to adenoma or carcioma of the cortex
cushing syndrome
cushing syndrome
manifestations
moon shaped face
truncal obesity
abnormal hairiness/ hirsutism
hypertension
•excessive androgen production during fetal period
•in femals -> masculinization of the external genitlia - enlargement of clitoris - virilization
- fused labia majora
Congenital Adrenal Hyperplasia
bronze tone of the skin
Addison disease
are two thick tubes which act to transport urine from the kidney to the bladder.
ureters
length of ureters
25 cm
arise in the abdomen as a continuation of the renal pelvis, and terminate in the pelvic cavity – where they empty into the bladder.
ureters
anatomical course of the ureters can therefore be divided into
- abdominal
* pelvic components
a funnel like structure located within the hilum of the kidney.
renal pelvis
The point at which the renal pelvis narrows to form the ureter is known as
ureteropelvic junction.
adrenal glands
and ureters are
a. intraperitoneal
b. retroperitoneal
b. retroperitoneal
Once within the pelvic cavity, the ureters travel down the lateral pelvic walls. At the level of the this structure, they turn anteromedially, moving in a transverse plane towards the bladder.
ischial spines
Upon reaching the bladder wall, the ureters pierce its lateral aspect in an ____ manner.
oblique
Ureters have a one way valve, where high ______ collapses the ureters – preventing the back-flow of urine.
intramural pressure
Approximately 2cm superior to the ischial spine, the ureters run underneath the____
uterine artery.
The ureter is a structure that has developed via this bud
ureteric bud from the mesonephric duct
The arterial supply to the ureters can be divided into abdominal and pelvic supply:
Abdominal – renal artery, testicular/ovarian artery, and ureteral branches directly from the abdominal aorta
Pelvic – superior and inferior vesical arteries.
nervous supply to the ureters
renal, testicular/ovarian and hypogastric plexuses.
Sensory fibres from the ureters enter the spinal cord at T11-L2, with ureteric pain referred to those dermatomal areas.
the presence of a solid stone in the urinary tract, formed from minerals within the urine. These can obstruct urinary flow, causing renal colic (an acute and severe loin pain) and haematuria (blood in the urine).
ureteric calculus
three locations where the ureters are at their narrowest – this is where a stone is more likely to become stuck:
Uretopelvic junction
Pelvic brim
Where the ureter enters the bladder
The gold standard investigation for suspected ureteric calculus is
CT scan of the kidneys, ureters and bladder (CT-KUB).
severe type of colicky pain and is referred through T11 - L2 dermatomes;
pain may radiate from the back above the iliac crest, through the ingunal region and into the scrotum or labia majora
renal colic