033 Healing and Repair Flashcards
What is the difference between labile, stable and permanent cells?
Labile cells are constantly being replaced
Stable cells can replicate when stimulated e.g. smooth muscle.
Permanent cells are incapable of organised replication e.g neurons, cardiac muscle and skeletal muscle
What is vascular endothelial growth factor?
This stimulates angiogenesis
During remodelling of wound, which collagen is substituted by which?
Type III is replaced by type I
Which nutrition factors influence healing?
Zinc, Vitamin C, protein
How do glucocorticoid drugs affect wound healing?
Inhibit inflammation - slow down the process
What causes exubant granulation tissue?
When excessive granulation tissue become physical barrier to regeneration of epithelium.
What is contracture?
When there is an exaggeration of normal wound contration, distorting surrounding structures
At what point does fibrin form blood clot in wound healing?
Immediately
What is a compound fracture?
Skin contact fracture
What occurs within 24-48 hours of wound?
Neutrophil recruitment
What is the difference in fibroblasts in secondary infections?
It becomes myofibroblast - with some characteristics of smooth muscle cells
When do macrophages arrive at wound site?
Days 3-7
What is a comminuted bone fracture?
Splinter in the bone fracture
When does cartilage begin to calcify during bone fractures?
During the second week
What do osteoclastic and osteoblastic cells do?
Osteoclastic removes old bone debris, osteoblastic cells deposit new debris.
