021 Antimicrobial Drugs Flashcards
What drug class is penicillin?
B lactam
What drugs can be used to inhibit protein synthesis?
Aminoglycosides and macrolides
What is a significant cause of healthcare associated infection?
C.difficile acquired disease that could lead to pseudomembranous collitis. When gut microbiota is damaged, this bacteria will replicate and cause damaged to the endothelium. It can cause gut to perforate and bleed out.
What drugs can be used to inhibit DNA synthesis?
Quinolones
Which drug is used to treat TB and how?
Rifampacin - It inhibits RNA polymerase
What drugs can be used to inhibit cell wall synthesis?
Glycopeptides by physical barrier and B lactams by inhibiting cell wall synthesis enzymes.
What drug class is cephalosporin?
B lactam
What drugs can be used to inhibit plasma membrane?
Fluroconzoles that interfere with ergosterol synthesis or antibacterial polymyxin B.
What is a consequence of using fluoroquinolones?
It can cause renal and cartilage damage. It is very damage and should be used topically.
What drugs can be used to inhibit folic acid synthesis?
Trimethoprim or sulphanamides, which inhibit the enzymes that synthesise folic acid by competitive inhibition. Purines and pyrimidines cannot be synthesized.
How does fluoconzole work?
Inhibit ergosterol synthesis on fungi
What is an example of a quinolones?
Ciprofloxacin, which inhibits supercoiling
What are some examples of antifolates?
Trimethoprim or sulphanamides
What drug class is erythromycin and clarithromycin? ?
Macrolides
What are examples of aminoglycosides?
Gentamicin, streptomycin,
