011 Innate Immunity

Question 1

What does the pentraxin family of plasma proteins do?

Answer 1

C reactive protein - help inflammation and assist in phagocytosis

Question 2

Which tissues/cells are toll like receptors found?

Answer 2

Toll like receptors are found only on immune cells

Question 3

Which tissues/cells are transmembrane proteins within endosomal membranes found?

Answer 3

Found in all tissue cells in the body

Question 4

Which TLR reacts with LPS?

Answer 4

TLR4

Question 5

Which TLR reacts with DNA?

Answer 5

TLR9

Question 6

What is the function of NOD like receptors and where are they found?

Answer 6

These receptors are found in the cytoplasm - they detect the intracellular PAMPS and activate cytoplasmic complex called the inflammasome.

Question 7

What is the main role of IL1

Answer 7

Inflammation

Question 8

What is the main role of IL6

Answer 8

B cell differentiation into plasma cells

Question 9

What is the systemic acute phase response?

Answer 9

The recruitment of cytokines that induce changes in plasma protein levels in the liver, which adjust thermostatic regulation of the hypothalamus to cause the fever.

Question 10

How does innate activation of IL1 occur?

Answer 10

This is a pre-existing protein. Innate immune responses of Nod-like receptors lead to activation of multiprotein inflammasome that cleaves IL1. This secretes IL1.

Question 11

What is the regulatory cytokine?

Answer 11

IL10

Question 12

What is Aicardi-Goutieres syndrome?

Answer 12

When there is a deficiency in the enzyme that clear up nucleic DNA. Innate immune response detect self molecules which then cause autoimmunity.

Question 13

Which immune response do we see most in acute infections?

Answer 13

Neutrophils

Question 14

Which immune response do we see most in chronic infections?

Answer 14

T-cells