XXVIII - Opioids

Question 1

Prototype opioid, full agonist, SE: miosis, respiratory depression, constipation, pruritus, urine retention

Answer 1

Morphine

Question 2

Severe pain, breakthrough cancer pain, lollipop, transdermal patch

Answer 2

Fentanyl

Question 3

Opioid choice for acute pancreatitis, does not cause niosis, SE: decrease seizure threshold (↑ seizures)

Answer 3

Meperidine (Normeperidine → seizures)

Question 4

Replacement therapy for opioid dependence

Answer 4

Methadone

Question 5

Antidote to opioid overdose

Answer 5

Naloxone

Question 6

Treatment for opioid dependence

Answer 6

Naltrexone

Question 7

Cough suppressive opioid

Answer 7

Dextromethorphan

Question 8

Opioids: shortest half-life

Answer 8

Remifentanil (3-4 min)

Question 9

Opioids: longest half-life

Answer 9

Buprenorphine (4-8 h)

Question 10

Signs of Opioid Overdose

Answer 10

Pupillary constriction, Coma, Respiratory depression

Question 11

Opioids Receptors: respiratory depression

Answer 11

μ

Question 12

Opioids Receptors: tolerance

Answer 12

δ

Question 13

Opioids Receptors: constipation

Answer 13

κ