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Pharmacology > Xantines > Flashcards

Xantines Flashcards

1
Q

name a xantine

A

Theophylline

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2
Q

what do they target?

A

phosphodiesterase

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3
Q

antagonist/ agonist?

A

inhibitor

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4
Q

how do they work ?

A

reduces breakdown of cAMP/cGMP
block adenosine receptors
activates histone deacetylase to reverse resistance to corticosteroid

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5
Q

what are they used for?

A

step 3/4 asthma

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6
Q

adverse effects?

A

dysrhythmia

seizures

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7
Q

prescribing advice

A

metabolized by P450 enzyme in liver
narrow therapeutic window
NOT with heart conditions , acute porphyria (rare hereditary disease in which there is abnormal metabolism of the blood pigment haemoglobin)
jaundice in neonates

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Pharmacology (18 decks)

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