Loop Diuretics Flashcards
1
Q
name two loop diuretics
A
furosemide
bumetanide
2
Q
what do they target?
A
Na+/K+/2Cl- co-transporter in the loop of Henle
3
Q
agonist/ antagonist
A
inhibitor
4
Q
what do they do?
A
reduces Na+, K+ and Cl- reabsorption
5
Q
special about them?
A
most powerful diuretic
excretion of 15-25% filtered Na+
6
Q
used for?
A
oedema
congestive heart failure
7
Q
adverse effects?
A
oto and nephrotoxicity hypotension decreased : na k ca
increased:
pH
Urea
8
Q
prescribing advice
A
NOT with aminoglycoside antibiotics
NOT with NSAIDS
