B2 adrenoceptor agonists Flashcards
1
Q
name two B2 andrenoceptor agonists
A
salbutamol (SABA)
Salmeterol ( LABA)
2
Q
what do they target?
A
B2 andrenoceptor on airway smooth muscle cells
3
Q
agonist/ antagonist ?
A
agonist
4
Q
how do they work ?
A
activate Gs protein to activate adenylate cyclase
producing cAMP
phosphorylates myosin light chain kinase
reduces [Ca+]
5
Q
overall effect?
A
bronchodilation
6
Q
used for?
A
acute relief of symptoms
prophylaxis of asthma
7
Q
adverse effects?
A
fine tremor of hands
dysrhythmias
hypokalaemia
8
Q
prescribing advice
A
inhaled to reduce systemic side effects
NOT with cardiovascular disease
