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Pharmacology > Nitrates > Flashcards

Nitrates Flashcards

1
Q

what do nitrates end in?

A

-nitrate

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2
Q

name three nitrates

A 
glyceryl trinitrate (GTN)
isosorbide dinitrate (ISD)
isosorbide mononitrate (ISM)
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3
Q

what receptor do they target?

A

endothelium derived relaxing factor receptor

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4
Q

agonist or antagonist ?

A

agonist

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5
Q

how do they work?

A

reacts with -SH group to release NO

stimulating guanylyl cyclase to dephosphorylate myosin light chain kinase and reduce [Ca2+]

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6
Q

what do they result in ?

A

vasodilation

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7
Q

what is GTN used for?

A

acute angina

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8
Q

what is ISD/ISM used for?

A

angina prophylaxis

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9
Q

adverse effects?

A 
headache
flushing 
hypotension
tachycardia
mathaemoglobinaemia
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10
Q

prescribing advice

A

GTN low oral bioavailability

nitrate tolerance reduced with ‘nitrate free interval’ or -SH donors

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Pharmacology (18 decks)

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