Muscarinic antagonists Flashcards
1
Q
name two muscarinic antagonists
A
Ipratropium (SAMA) Tiotropium bromide (LAMA)
2
Q
what do muscarinic antagonists usually end in ?
A
-ium
3
Q
what do they target?
A
M3 muscarinic cholinoceptors on airway smooth muscle cells
4
Q
agonist/antagonist ??
A
Antagonist
5
Q
how do they work?
A
prevent activation of Gq protein in the parasympathetic response
6
Q
what is their overall effect?
A
reduces bronchospasm and mucous secretion
7
Q
what are they used for?
A
maintenance of COPD
8
Q
adverse effects?
A
dry mouth
9
Q
prescribing advice?
A
inhaled to reduce systemic side effects
NOT with prostatic hyperplasia, angle-closure glaucoma
